van Miert A S, van Duin C T
Arzneimittelforschung. 1978;28(12):2246-51.
A study of the antipyretic effect of polymyxin B was undertaken to determine how this agent reduces fever in rabbits. It involved the effects of the drug: (1) on fever induced by exogenous pyrogenes (E. coli lipopolysaccharide, synthetic double-stranded ribonucleic acid, sodium nucleinate from yeast) and leucocytic pyrogen, (2) on the release of endogenous pyrogen in vivo and in vitro, and (3) on leucocytic and exogenous pyrogens in vitro. The results indicate that polymyxin B produces an antipyretic effect in endotoxin-induced fever primarily by an interaction of this cationic macromolecule with the anionic endotoxin molecule. Further it is likely that polymyxin B inhibits endogenous pyrogen synthesis and/or release from polymorphonuclear leucocytes.
开展了一项关于多粘菌素B解热作用的研究，以确定该药物如何降低家兔的体温。该研究涉及该药物的以下作用：（1）对外源性致热原（大肠杆菌脂多糖、合成双链核糖核酸、酵母核酸钠）和白细胞致热原诱导的发热的作用；（2）对体内和体外内源性致热原释放的作用；（3）对体外白细胞和外源性致热原的作用。结果表明，多粘菌素B在内毒素诱导的发热中产生解热作用，主要是通过这种阳离子大分子与阴离子内毒素分子的相互作用。此外，多粘菌素B可能抑制内源性致热原的合成和/或从多形核白细胞的释放。
