Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, India; Department of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.
Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, India.
J Environ Pathol Toxicol Oncol. 2021;40(1):43-50. doi: 10.1615/JEnvironPatholToxicolOncol.2020035783.
Exposure to organochlorine pesticides (OCPs) may be a risk factor for breast cancer (BC). Their role may be more relevant in developing countries such as India, where an abundance of these products is used for agricultural purposes. The present study compares OCP tissue levels in patients who underwent BC surgery (group A) or patients who had surgery for excision of breast fibroadenoma (group B). We perform OCP level quantification using a PerkinElmer, Inc. (Waltham, MA) gas chromatograph (GC) that is equipped with a 63Ni selective electron-capture detector. Significantly higher breast tissue OCP levels are present in the study population, indicating significant exposure. We detect 18 different types of OPCs in study subjects, with six OPCs (γ-hexachlorocyclohexane [HCH], δ-HCH, endrin, endosulfan-II, p,p'-dichlorodiphenyldichloroenthane [DDD], and p,p'-dichlorodiphenyltrichloroenthane [DDT]) present in all subjects. Endosulfan-II, p,p'-DDT, and p,p'-DDD tissue levels are significantly higher in BC patients than in those with fibroadenoma. Higher tissue levels of OCPs (α-HCH) are significantly associated with the presence of extracapsular spread (1.42 vs. 0.91; p = 0.04) and higher disease stage (early BC vs. locally advanced BC; 18.90 vs. 11.90; p = 0.04). The present pilot study indicates higher OCP tissue levels in northern India BC patients compared to patients with fibroadenoma.
接触有机氯农药 (OCPs) 可能是乳腺癌 (BC) 的一个风险因素。在印度等发展中国家，这些产品大量用于农业，其作用可能更为相关。本研究比较了接受 BC 手术的患者（A 组）或接受乳房纤维腺瘤切除术的患者（B 组）的 OCP 组织水平。我们使用配备有 63Ni 选择性电子俘获检测器的 PerkinElmer，Inc. (Waltham，MA) 气相色谱仪 (GC) 定量 OCP 水平。研究人群的乳房组织 OCP 水平显著升高，表明存在显著暴露。我们在研究对象中检测到 18 种不同类型的 OPCs，其中 6 种 OPCs（γ-六氯环己烷 [HCH]、δ-HCH、艾氏剂、硫丹-II、p,p'-二氯二苯二氯乙烷 [DDD] 和 p,p'-二氯二苯三氯乙烷 [DDT]）存在于所有研究对象中。BC 患者的硫丹-II、p,p'-DDT 和 p,p'-DDD 组织水平明显高于纤维腺瘤患者。OCPs（α-HCH）的组织水平较高与囊外扩散的存在显著相关（1.42 与 0.91；p = 0.04）和疾病分期较高（早期 BC 与局部晚期 BC；18.90 与 11.90；p = 0.04）。本初步研究表明，与纤维腺瘤患者相比，印度北部 BC 患者的 OCP 组织水平更高。
