长链非编码 RNA 作为骨肉瘤临床结局预后标志物的价值：一项荟萃分析。
The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis.
机构信息
Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
出版信息
BMC Cancer. 2021 Feb 27;21(1):202. doi: 10.1186/s12885-021-07882-w.
BACKGROUND
In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis.
METHODS
Literature retrieval was conducted by searching PubMed, Web of Science and the Cochrane Library (last update by October 2, 2019). A meta-analysis was performed to explore association between lncRNAs expression and overall survival (OS) of osteosarcoma patients. Relationships between lncRNAs expression and other clinicopathological features were also analyzed respectively.
RESULTS
Overall, 4351 patients from 62 studies were included in this meta-analysis and 25 lncRNAs were identified. Pooled analyses showed that high expression of 14 lncRNAs connoted worse OS, while two lncRNAs were associated with positive outcome. Further, analysis toward osteosarcoma clinicopathologic features demonstrated that overexpression of TUG1 and XIST indicated poor clinical parameters of patients.
CONCLUSIONS
This meta-analysis has elucidated the prognostic potential of 16 lncRNAs in human osteosarcoma. Evidently, desperate expression and functional targets of these lncRNAs offer new approaches for prognosis and therapy of osteosarcoma.
背景
近年来，新兴研究表明长链非编码 RNA（lncRNA）在骨肉瘤中具有重要的功能和潜在的临床应用。为了进一步验证多个 lncRNA 的预后价值，我们进行了这项更新的荟萃分析。
方法
通过检索 PubMed、Web of Science 和 Cochrane Library（截至 2019 年 10 月 2 日最后更新）进行文献检索。进行荟萃分析以探讨 lncRNA 表达与骨肉瘤患者总生存率（OS）之间的关系。还分别分析了 lncRNA 表达与其他临床病理特征之间的关系。
结果
总体而言，这项荟萃分析纳入了 62 项研究中的 4351 名患者，鉴定出 25 个 lncRNA。荟萃分析结果表明，14 个 lncRNA 的高表达预示着 OS 较差，而两个 lncRNA 与良好的预后相关。此外，对骨肉瘤临床病理特征的分析表明，TUG1 和 XIST 的过表达表明患者具有较差的临床参数。
结论
这项荟萃分析阐明了 16 个 lncRNA 在人类骨肉瘤中的预后潜力。显然，这些 lncRNA 的过度表达及其功能靶点为骨肉瘤的预后和治疗提供了新的方法。
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