文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

鉴定与骨肉瘤总生存期相关的 N6-甲基腺苷相关长非编码 RNA 生物标志物。

Identification of N6-methylandenosine related LncRNAs biomarkers associated with the overall survival of osteosarcoma.

机构信息

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

Department of Joint surgery, Huangshan City People's Hospital, Huangshan, Anhui, China.

出版信息

BMC Cancer. 2021 Dec 1;21(1):1285. doi: 10.1186/s12885-021-09011-z.

DOI:10.1186/s12885-021-09011-z
PMID:34852770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8638368/
Abstract

PURPOSE: Osteosarcoma (OS) is a differentiation disease caused by the genetic and epigenetic differentiation of mesenchymal stem cells into osteoblasts. OS is a common, highly malignant tumor in children and adolescents. Fifteen to 20 % of the patients find distant metastases at their first visit. The purpose of our study was to identify biomarkers for tracking the prognosis and treatment of OS to improve the survival rate of patients. MATERIALS AND METHODS: In this study, which was based on Therapeutically Applicable Research to Generate Effective Treatments (TARGET), we searched for m6A related lncRNAs in OS. We constructed a network between lncRNA and m6A, and built an OS prognostic risk model. RESULTS: We identified 14,581 lncRNAs by using the dataset from TARGET. We obtained 111 m6A-related lncRNAs through a Pearson correlation analysis. A network was built between lncRNA and m6A genes. Eight m6A-related lncRNAs associated with survival were identified through a univariate Cox analysis. A selection operator (LASSO) Cox regression was used to construct a prognostic risk model with six genes (RP11-286E11.1, LINC01426, AC010127.3, DLGAP1-AS2, RP4-657D16.3, AC002398.11) obtained through least absolute shrinkage. We also discovered upregulated levels of DLGAP1-AS2 and m6A methylation in osteosarcoma tissues/cells compared with normal tissues/osteoblasts cells. CONCLUSION: We constructed a risk score prognosis model of m6A-related lncRNAs (RP11-286E11.1, LINC01426, AC010127.3, DLGAP1-AS2, RP4-657D16.3, AC002398.11) using the dataset downloaded from TRAGET. We verified the value of the model by dividing all samples into test groups and training groups. However, the role of m6A-related lncRNAs in osteosarcoma needs to be further researched by cell and in vivo studies.

摘要

目的：骨肉瘤（OS）是一种分化性疾病，由间充质干细胞向成骨细胞的遗传和表观遗传分化引起。OS 是儿童和青少年中常见的高度恶性肿瘤。15%至 20%的患者在首次就诊时发现远处转移。本研究的目的是确定用于跟踪 OS 预后和治疗的生物标志物，以提高患者的生存率。

材料和方法：在这项基于治疗性应用研究以产生有效治疗方法（TARGET）的研究中，我们在 OS 中搜索了 m6A 相关的 lncRNA。我们构建了 lncRNA 和 m6A 之间的网络，并构建了 OS 预后风险模型。

结果：我们使用 TARGET 数据集鉴定了 14581 个 lncRNA。通过 Pearson 相关性分析获得了 111 个 m6A 相关 lncRNA。构建了 lncRNA 和 m6A 基因之间的网络。通过单因素 Cox 分析鉴定了 8 个与生存相关的 m6A 相关 lncRNA。使用选择算子（LASSO）Cox 回归构建了一个包含六个基因（RP11-286E11.1、LINC01426、AC010127.3、DLGAP1-AS2、RP4-657D16.3、AC002398.11）的预后风险模型，这些基因是通过最小绝对收缩和选择算法获得的。我们还发现与正常组织/成骨细胞相比，骨肉瘤组织/细胞中 DLGAP1-AS2 和 m6A 甲基化水平升高。

结论：我们使用从 TRAGET 下载的数据集构建了一个 m6A 相关 lncRNA（RP11-286E11.1、LINC01426、AC010127.3、DLGAP1-AS2、RP4-657D16.3、AC002398.11）的风险评分预后模型。我们通过将所有样本分为测试组和训练组来验证模型的价值。然而，m6A 相关 lncRNAs 在骨肉瘤中的作用需要通过细胞和体内研究进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/a2e077733d91/12885_2021_9011_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/e7f973e6a58e/12885_2021_9011_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/f0747c284210/12885_2021_9011_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/14e2946ba2a7/12885_2021_9011_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/1fd3fc85c326/12885_2021_9011_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/1db745aa5cf6/12885_2021_9011_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/b5bd0d1d6b5c/12885_2021_9011_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/446ac273eafd/12885_2021_9011_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/00938738b02a/12885_2021_9011_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/9712e42a9193/12885_2021_9011_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/d9fc59cffdf3/12885_2021_9011_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/a2e077733d91/12885_2021_9011_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/e7f973e6a58e/12885_2021_9011_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/f0747c284210/12885_2021_9011_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/14e2946ba2a7/12885_2021_9011_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/1fd3fc85c326/12885_2021_9011_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/1db745aa5cf6/12885_2021_9011_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/b5bd0d1d6b5c/12885_2021_9011_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/446ac273eafd/12885_2021_9011_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/00938738b02a/12885_2021_9011_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/9712e42a9193/12885_2021_9011_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/d9fc59cffdf3/12885_2021_9011_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/8638368/a2e077733d91/12885_2021_9011_Fig11_HTML.jpg

相似文献

[1]
Identification of N6-methylandenosine related LncRNAs biomarkers associated with the overall survival of osteosarcoma.

BMC Cancer. 2021-12-1

[2]
N6-methyladenosine Modification-Related Long Non-Coding RNAs are Potential Biomarkers for Predicting the Prognosis of Patients With Osteosarcoma.

Technol Cancer Res Treat. 2022

[3]
N6-Methyladenosine-Related LncRNAs Are Potential Remodeling Indicators in the Tumor Microenvironment and Prognostic Markers in Osteosarcoma.

Front Immunol. 2021

[4]
N6-methylandenosine-related lncRNAs play an important role in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma.

Sci Rep. 2021-9-8

[5]
The prognostic value and immune landscapes of m1A/m5C/m6A-associated lncRNA signature in osteosarcoma.

Eur Rev Med Pharmacol Sci. 2022-8

[6]
N6-Methyladenosine-Related lncRNA Signature Predicts the Overall Survival of Colorectal Cancer Patients.

Genes (Basel). 2021-8-31

[7]
Analysis of N6-methyladenosine-related lncRNAs in the tumor immune microenvironment and their prognostic role in pancreatic cancer.

J Cancer Res Clin Oncol. 2022-7

[8]
An effective N6-methyladenosine-related long non-coding RNA prognostic signature for predicting the prognosis of patients with bladder cancer.

BMC Cancer. 2021-11-21

[9]
Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs.

Eur J Med Res. 2024-8-8

[10]
N6-methyladenosine-related lncRNAs identified as potential biomarkers for predicting the overall survival of Asian gastric cancer patients.

BMC Cancer. 2022-7-1

引用本文的文献

[1]
Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway.

J Bone Oncol. 2023-1-3

[2]
The development and validation of a m6A-lncRNAs based prognostic model for overall survival in lung squamous cell carcinoma.

J Thorac Dis. 2022-10

[3]
Identification and validation of ferroptosis-related lncRNA signatures as a novel prognostic model for glioma.

Front Genet. 2022-9-20

[4]
m6A-related lncRNAs are potential biomarkers for the prognosis of COAD patients.

Front Oncol. 2022-8-30

[5]
Novel insights into the interaction between N6-methyladenosine methylation and noncoding RNAs in musculoskeletal disorders.

Cell Prolif. 2022-10

本文引用的文献

[1]
LncRNA RCAT1 promotes tumor progression and metastasis via miR-214-5p/E2F2 axis in renal cell carcinoma.

Cell Death Dis. 2021-7-9

[2]
N-methyladenosine (mA) in pancreatic cancer: Regulatory mechanisms and future direction.

Int J Biol Sci. 2021

[3]
The Role of -Methyladenosine Modified Circular RNA in Pathophysiological Processes.

Int J Biol Sci. 2021

[4]
Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p.

Onco Targets Ther. 2021-7-2

[5]
Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells.

J Cancer. 2021-6-11

[6]
The lncRNA Gene rs2151280 GG Genotype is Associated with Increased Susceptibility to Recurrent Miscarriage in a Southern Chinese Population.

J Inflamm Res. 2021-6-30

[7]
The Emerging Roles of RNA mA Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance.

Cancer Res. 2021-7-1

[8]
LINC00174 Facilitates Cell Proliferation, Cell Migration and Tumor Growth of Osteosarcoma Regulating the TGF-β/SMAD Signaling Pathway and Upregulating SSH2 Expression.

Front Mol Biosci. 2021-6-17

[9]
Rhaponticin suppresses osteosarcoma through the inhibition of PI3K-Akt-mTOR pathway.

Saudi J Biol Sci. 2021-7

[10]
ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B.

Mol Carcinog. 2021-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索