老年人动力缺乏性肥胖与脂代谢和糖代谢紊乱及代谢综合征的相关性：SABE 研究结果

Dynapenic obesity as an associated factor to lipid and glucose metabolism disorders and metabolic syndrome in older adults - Findings from SABE Study.

机构信息

Department of Epidemiology and Public Health, University College London, London, UK; Gerontology Department, Federal University of São Carlos, São Carlos, Brazil.

Department of Science of Physical Activity, Montreal, Canada.

出版信息

Clin Nutr. 2018 Aug;37(4):1360-1366. doi: 10.1016/j.clnu.2017.06.009. Epub 2017 Jun 10.

DOI:10.1016/j.clnu.2017.06.009

PMID:28647293

Abstract

BACKGROUND & AIMS: There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo.

METHODS

This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010. Based on waist circumference (>88 cm women and >102 cm men) and handgrip strength (<16 kg women and <26 kg men), four groups were identified: non-dynapenic/non-abdominal obese (ND/NAO), abdominal obese alone (AOA), dynapenic alone (DA) and dynapenic/abdominal obese (D/AO). Dependent variables were blood pressure, lipid profile, fasting glucose and glycated-haemoglobin, metabolic syndrome and cardiovascular diseases. Logistic regression was used to analyze the associations between dynapenia and abdominal obesity status and lipid and glucose metabolic profiles, blood pressure, cardiovascular diseases and metabolic syndrome.

RESULTS

The fully adjusted models showed that D/AO individuals had higher prevalence of low HDL plasma concentrations (OR = 2.51, 95%CI: 1.40-4.48), hypertriglyceridemia (OR = 2.53, 95%CI: 1.43-4.47), hyperglycemia (OR = 2.05, 95%CI: 1.14-3.69), high glycated-haemoglobin concentrations (OR = 1.84, 95%CI: 1.03-3.30) and metabolic syndrome (OR = 12.39, 95%CI: 7.38-20.79) than ND/NAO. Dynapenic and D/AO individuals had higher prevalence of heart disease (OR = 2.05, 95%CI: 1.17-3.59 and OR = 1.92, 95%CI: 1.06-3.48, respectively) than ND/NAO.

CONCLUSION

D/AO was associated with high prevalence of lipid and glucose metabolism disorders and metabolic syndrome while dynapenia and D/AO were associated with high prevalence of heart disease.

摘要

背景与目的

目前鲜有证据表明动力性肥胖与脂代谢和糖代谢紊乱、高血压、慢性病和代谢综合征有关。本研究旨在分析在圣保罗居住的老年人中，动力性腹型肥胖是否与脂代谢和糖代谢紊乱、高血压、代谢综合征和心血管疾病相关。

方法

本横断面研究纳入了 2010 年参加第三次圣保罗健康、幸福与老龄化研究的 833 名老年人。根据腰围（女性>88cm，男性>102cm）和握力（女性<16kg，男性<26kg），将参与者分为 4 组：非动力性/非腹型肥胖（ND/NAO）、单纯腹型肥胖（AOA）、单纯动力性衰弱（DA）和动力性/腹型肥胖（D/AO）。血压、血脂谱、空腹血糖和糖化血红蛋白、代谢综合征和心血管疾病为因变量。采用 logistic 回归分析动力性衰弱和腹型肥胖状态与脂代谢和糖代谢特征、血压、心血管疾病和代谢综合征之间的关系。

结果

在完全调整模型中，D/AO 个体的低 HDL 血浆浓度（OR=2.51，95%CI：1.40-4.48）、高甘油三酯血症（OR=2.53，95%CI：1.43-4.47）、高血糖（OR=2.05，95%CI：1.14-3.69）、高糖化血红蛋白浓度（OR=1.84，95%CI：1.03-3.30）和代谢综合征（OR=12.39，95%CI：7.38-20.79）的患病率均高于 ND/NAO。与 ND/NAO 相比，动力性衰弱和 D/AO 个体患心脏病（OR=2.05，95%CI：1.17-3.59 和 OR=1.92，95%CI：1.06-3.48）的患病率更高。