Kuraitis Drew, Rosenthal Nadia, Boh Erin, McBurney Elizabeth
Department of Dermatology, Tulane University, New Orleans, USA.
The Jackson Laboratory, Bar Harbor, USA.
Arch Dermatol Res. 2022 Mar;314(2):133-140. doi: 10.1007/s00403-021-02207-0. Epub 2021 Feb 28.
The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.
巨噬细胞生物学领域正在迅速发展。最近的研究已将重点从经典的伤口愈合作用转向皮肤病病理学中新发现的作用。这些研究已确定巨噬细胞在相对常见的病症（如银屑病、皮肤癌和皮肤T细胞淋巴瘤）中的致病作用。选择性清除这些细胞或其相关细胞因子可改善临床结果。在此，我们综述了最近的动物和人体研究，这些研究阐明了巨噬细胞在皮肤科医生经常遇到的病症中的新致病作用，并讨论了临床上相关的针对巨噬细胞的疗法。
