Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald D-17475, Germany.
Exp Biol Med (Maywood). 2021 May;246(9):1112-1120. doi: 10.1177/1535370221994086. Epub 2021 Feb 27.
The Wnt signaling pathway regulates physiological processes such as cell proliferation and differentiation, cell fate decisions, and stem cell maintenance and, thus, plays essential roles in embryonic development, but also in adult tissue homeostasis and repair. The Wnt signaling pathway has been associated with heart development and repair and has been shown to be crucially involved in proliferation and differentiation of progenitor cells into cardiomyocytes. The investigation of the role of the Wnt signaling pathway and the regulation of its expression/activity in atrial fibrillation has only just begun. The present minireview (I) provides original data regarding the expression of Wnt signaling components in atrial tissue of patients with atrial fibrillation or sinus rhythm and (II) summarizes the current state of knowledge of the regulation of Wnt signaling components' expression/activity and the contribution of the various levels of the Wnt signal transduction pathway to the processes of the development, maintenance, and progression of atrial fibrillation.
Wnt 信号通路调节细胞增殖和分化、细胞命运决定以及干细胞维持等生理过程，因此在胚胎发育中发挥着重要作用，但也在成人组织稳态和修复中发挥着重要作用。Wnt 信号通路与心脏发育和修复有关，并被证明在祖细胞向心肌细胞的增殖和分化中起着至关重要的作用。Wnt 信号通路的作用及其在心房颤动中的表达/活性调节的研究才刚刚开始。这篇迷你综述（I）提供了关于在心房颤动或窦性节律患者的心房组织中 Wnt 信号成分表达的原始数据，（II）总结了目前关于 Wnt 信号成分表达/活性调节的知识状态以及各种水平的 Wnt 信号转导通路对心房颤动的发展、维持和进展过程的贡献。
