Laboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Free Radic Res. 2021 Jun;55(6):655-670. doi: 10.1080/10715762.2021.1892091. Epub 2021 Mar 1.
Tuberculosis (TB) is a chronic pulmonary disease caused by which is a major cause of morbidity and mortality worldwide. Due to the complexity of disease and its continuous global spread, there is an urgent need to improvise the strategies for prevention, diagnosis, and treatment. The current anti-TB regimen lasts for months and warrants strict compliance to clear infection and to minimize the risk of development of multi drug-resistant tuberculosis. This underscores the need to have new and improved therapeutics for TB treatment. Several studies have highlighted the unique ability of to exploit host factors to support its survival inside the intracellular environment. One of the key players to mycobacterial disease susceptibility and infection are endogenous gases such as oxygen, nitric oxide, carbon monoxide and hydrogen sulfide. Nitric oxide and carbon monoxide as the physiological gaseous messengers are considered important to the outcome of infection. The role of hydrogen sulfide in human tuberculosis is yet not fully elucidated, but this gas has been shown to play a significant role in bacterial respiration, growth and pathogenesis. This review will focus on the host factors majorly endogenous gaseous signaling molecules which contributes to survival inside the intracellular environment and highlight the potential therapeutic targets.
结核病（TB）是一种慢性肺部疾病，由 引起，是全球发病率和死亡率的主要原因。由于疾病的复杂性及其在全球范围内的持续传播，迫切需要改进预防、诊断和治疗策略。目前的抗结核方案需要持续数月，需要严格遵守以清除感染并最大程度降低发展为耐多药结核病的风险。这凸显了对结核病治疗有新的和改进的治疗方法的需求。多项研究强调了 利用宿主因素在细胞内环境中支持其存活的独特能力。导致分枝杆菌病易感性和感染的关键因素之一是内源性气体，如氧气、一氧化氮、一氧化碳和硫化氢。一氧化氮和一氧化碳作为生理气体信使，被认为对 感染的结果很重要。硫化氢在人类结核病中的作用尚未完全阐明，但这种气体已被证明在细菌呼吸、生长和发病机制中发挥重要作用。这篇综述将重点介绍主要在细胞内环境中有助于 存活的宿主因素——内源性气态信号分子，并强调潜在的治疗靶点。
