Institute of Glocal Disease Control, Konkuk University, Seoul, Republic of Korea.
Department of Biomedical Science and Engineering, Konkuk University, Seoul, Republic of Korea.
Plant Signal Behav. 2021 May 4;16(5):1893978. doi: 10.1080/15592324.2021.1893978. Epub 2021 Mar 1.
Cold stress is a major environmental constraint that restrains plant growth and productivity. To cope with cold stress, plants must be able to perceive a cold signal and regulate the expression of cold-regulated () genes. In our recent study, we showed that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15) acts as a substrate receptor for CULLIN4-based ubiquitin E3 ligase complex to promote cold-induced histone deacetylase 2 C (HD2C) degradation that allows the activation of genes. Additionally, we found that POWERDRESS (PWR), a HOS15-interacting protein, is required for the association of HOS15 with gene chromatin and HD2C degradation. The HOS15/PWR complex interacts with and recruits CBF transcription factors to the promoters of genes. Collectively, our previous findings suggest that HOS15 and PWR function as positive regulators for the expression of genes, and promote cold tolerance. Accordingly, we herein discuss the role of PWR in cold tolerance.
冷胁迫是限制植物生长和生产力的主要环境约束因素。为了应对冷胁迫，植物必须能够感知冷信号并调节冷调节基因的表达。在我们最近的研究中，我们表明高表达渗透响应基因 15（HOS15）作为 CULLIN4 基泛素 E3 连接酶复合物的底物受体，促进冷诱导的组蛋白去乙酰化酶 2C（HD2C）降解，从而激活基因的表达。此外，我们发现 HOS15 相互作用蛋白 POWERDRESS（PWR）是 HOS15 与基因染色质结合和 HD2C 降解所必需的。HOS15/PWR 复合物与 CBF 转录因子相互作用，并将其募集到基因的启动子上。总之，我们之前的研究结果表明，HOS15 和 PWR 作为基因表达的正调控因子，促进了植物的耐寒性。因此，我们在此讨论了 PWR 在耐寒性中的作用。
