Centro Universitário de Mineiros - UNIFIMES, Rua 23, esquina com Av. Caiapós - Setor Aeroporto, Mineiros, GO, Brazil.
EQUINOVA Research Group, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, campus Pampulha, Belo Horizonte, MG 31270-901, Brazil.
Vet J. 2021 Apr;270:105627. doi: 10.1016/j.tvjl.2021.105627. Epub 2021 Feb 5.
This study aimed to characterize and correlate physiological and metabolic changes in horses fed a hypercaloric diet (HD). Nine mature horses with a mean initial body condition score of 2.9 ± 1 (scale, 1-9) were fed a high-calorie diet for 5 months. Fasting blood samples were collected before the study and biweekly for the duration of the project to determine the concentrations of cholesterol (CHOL), very low (VLDL), low (LDL) and high-density (HDL) lipoproteins, triglycerides, non-esterified fatty acids, and fructosamine. A low-dose oral glucose tolerance test (LGTT) was conducted before, 75 and 150 days after HD introduction. Mean arterial blood pressure was measured monthly. Following HD introduction, CHOL, LDL, HDL, and fructosamine blood concentrations increased (P < 0.001). These four variables were also positively and significantly correlated with the blood insulin response to LGTT. These findings confirm the occurrence of hypercholesterolemia concomitantly with insulin dysregulation development in horses exposed to HD.
本研究旨在描述和分析给予高热卡饮食（HD）的马匹的生理和代谢变化，并进行相关性分析。9 匹初始体况评分为 2.9±1（1-9 分制）的成熟马匹接受高热卡饮食 5 个月。在研究前和项目持续期间每两周采集一次空腹血样，以测定胆固醇（CHOL）、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）脂蛋白、甘油三酯、非酯化脂肪酸和果糖胺的浓度。在引入 HD 前、75 天和 150 天后进行低剂量口服葡萄糖耐量试验（LGTT）。每月测量平均动脉血压。引入 HD 后，CHOL、LDL、HDL 和果糖胺的血液浓度增加（P<0.001）。这四个变量与 LGTT 时的胰岛素反应呈正相关且有显著意义。这些发现证实了暴露于 HD 的马匹发生高胆固醇血症同时伴有胰岛素调节功能紊乱。
