Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas - Universidade de São Paulo, São Paulo, SP, Brazil.
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas - Universidade de São Paulo, São Paulo, SP, Brazil.
Food Res Int. 2021 Mar;141:110139. doi: 10.1016/j.foodres.2021.110139. Epub 2021 Jan 19.
Jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian native fruit belonging to the Myrtaceae family. Previously it was demonstrated that phenolic-rich extracts from jaboticaba (PEJ) possess health-beneficial properties in diet-induced obesity; however, whether PEJ modulates the obesity-associated intestinal inflammatory status remains unclear. Thus, male C57BL/6J obese mice were fed a high-fat-sugar (HFS) diet and received PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) (PEJ1 group), and 100 mg GAE/kg BW (PEJ2 group), or water (HFS group) by oral gavage for 14 weeks. PEJ groups presented a reduced body weight gain and adiposity and were protected against insulin resistance and dyslipidemia. In addition, PEJ prevented metabolic endotoxemia linked to an attenuation of the HFS diet-induced intestinal inflammation via down-regulation of pro-inflammatory mediators such as tumor necrosis factor (TNF-α), membrane transporter toll-like receptor-4 (TLR-4) and nuclear factor-κB (NF-κB) in the colon. These anti-inflammatory effects appear to be involved, at least in part, with an inhibition of the colonic inflammasome pathway of obese mice.
嘉宝果（Plinia jaboticaba (Vell.) Berg）是一种原产于巴西的水果，属于桃金娘科。先前的研究表明，富含酚类的嘉宝果提取物（PEJ）在饮食诱导的肥胖中具有有益健康的特性；然而，PEJ 是否调节肥胖相关的肠道炎症状态尚不清楚。因此，雄性 C57BL/6J 肥胖小鼠喂食高脂肪高糖（HFS）饮食，并通过口服灌胃接受两种剂量的 50mg 没食子酸当量（GAE）/kg 体重（BW）（PEJ1 组）和 100mg GAE/kg BW（PEJ2 组）的 PEJ，或水（HFS 组），共 14 周。PEJ 组体重增加和肥胖减少，并防止了胰岛素抵抗和血脂异常。此外，PEJ 通过下调肿瘤坏死因子（TNF-α）、膜转运蛋白 toll 样受体 4（TLR-4）和核因子-κB（NF-κB）等促炎介质，预防了与代谢性内毒素血症相关的 HFS 饮食诱导的肠道炎症，从而起到保护作用。在结肠中。这些抗炎作用似乎至少部分涉及抑制肥胖小鼠的结肠炎症小体途径。
