Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas - Universidade de São Paulo, São Paulo, SP, Brazil.
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas - Universidade de São Paulo, São Paulo, SP, Brazil; Food Research Center FoRC, University of São Paulo, São Paulo, SP, Brazil.
Food Res Int. 2021 May;143:110302. doi: 10.1016/j.foodres.2021.110302. Epub 2021 Mar 10.
Obesity is a critical public health problem worldwide that has been associated to non-communicable diseases (NCD), such as type 2 diabetes (T2DM), non-alcoholic fatty lipid diseases (NAFLD) and inflammatory diseases. Polyphenols from several food sources have been studied as one option against these health problems. Sabara jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian berry rich in ellagic acid derivatives and anthocyanins. Here we investigated the effects of a phenolic-rich extract from Sabara jaboticaba (PEJ) in a diet-induced obesity animal model. PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) and 100 mg GAE/kg BW, were administered by daily gavage to obese C57BL/6J mice for 14 weeks. PEJ prevented the excessive body weight and adiposity, adipocyte hypertrophy, inflammation, hyperglycemia, glucose intolerance, insulin resistance, hypercholesterolemia, and hepatic lipid accumulation, as well as increased energy expenditure. In conclusion, polyphenols from Sabara jaboticaba presented several powerful therapeutic properties relevant for fighting obesity and associated health problems.
肥胖是全球范围内的一个重大公共卫生问题，与非传染性疾病（NCD）有关，如 2 型糖尿病（T2DM）、非酒精性脂肪性肝病（NAFLD）和炎症性疾病。几种食物来源的多酚已被研究作为对抗这些健康问题的一种选择。Sabara jaboticaba（Plinia jaboticaba（Vell.）Berg）是一种巴西浆果，富含鞣花酸衍生物和花青素。在这里，我们研究了富含 Sabara jaboticaba 多酚的提取物（PEJ）在饮食诱导肥胖动物模型中的作用。PEJ 以 50mg 没食子酸当量（GAE）/kg 体重（BW）和 100mg GAE/kg BW 的两个剂量通过每日灌胃给予肥胖 C57BL/6J 小鼠 14 周。PEJ 可预防体重和肥胖过度、脂肪细胞肥大、炎症、高血糖、葡萄糖不耐受、胰岛素抵抗、高胆固醇血症和肝脂质堆积，以及增加能量消耗。总之，Sabara jaboticaba 的多酚具有多种相关的强大治疗特性，可用于对抗肥胖及其相关健康问题。
