Sack D A, Duncan W, Rosenthal N E, Mendelson W E, Wehr T A
Clinical Psychobiology Branch, National Institute of Mental Health, Maryland.
Acta Psychiatr Scand. 1988 Feb;77(2):219-24. doi: 10.1111/j.1600-0447.1988.tb05104.x.
The antidepressant response to partial sleep deprivation early in the night (PSD-E) was compared with the response to partial sleep deprivation late in the night (PSD-L) in 16 drug-free depressed inpatients using a balanced order crossover design. PSD-L had a significantly greater antidepressant effect that PSD-E. The response to PSD-L was sustained and enhanced by a second night of treatment. Patients had significantly shorter sleep durations and reduced REM sleep on PSD-L that did not occur in the PSD-E situation. There was a significant negative correlation between response to PSD and sleep duration, and in particular, REM sleep duration, in the late sleep deprivation situation. Thus, the amount and timing of sleep appear to be factors in the response to PSD, but additional studies are needed to evaluate the relative importance of these parameters.
采用平衡顺序交叉设计，对16名未服用药物的住院抑郁症患者比较了夜间早期部分睡眠剥夺（PSD-E）与夜间晚期部分睡眠剥夺（PSD-L）的抗抑郁反应。PSD-L的抗抑郁作用明显大于PSD-E。PSD-L的反应在第二个治疗夜间得以持续并增强。患者在PSD-L时睡眠时间显著缩短，快速眼动睡眠减少，而在PSD-E情况下则未出现这种情况。在晚期睡眠剥夺情况下，PSD反应与睡眠时间尤其是快速眼动睡眠时间之间存在显著负相关。因此，睡眠量和时间似乎是影响PSD反应的因素，但还需要更多研究来评估这些参数的相对重要性。
