Matsuda Daiki, Moriuchi Takefumi, Ikio Yuta, Mitsunaga Wataru, Fujiwara Kengo, Matsuo Moemi, Nakamura Jiro, Suzuki Tomotaka, Sugawara Kenichi, Higashi Toshio
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Department of Occupational Therapy, Nagasaki Memorial Hospital, Nagasaki, Japan.
Front Hum Neurosci. 2021 Feb 12;15:637401. doi: 10.3389/fnhum.2021.637401. eCollection 2021.
This study aimed to investigate whether the effect of mental practice (motor imagery training) can be enhanced by providing neurofeedback based on transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEP). Twenty-four healthy, right-handed subjects were enrolled in this study. The subjects were randomly allocated into two groups: a group that was given correct TMS feedback (Real-FB group) and a group that was given randomized false TMS feedback (Sham-FB group). The subjects imagined pushing the switch with just timing, when the target circle overlapped a cross at the center of the computer monitor. In the Real-FB group, feedback was provided to the subjects based on the MEP amplitude measured in the trial immediately preceding motor imagery. In contrast, the subjects of the Sham-FB group were provided with a feedback value that was independent of the MEP amplitude. TMS was applied when the target, moving from right to left, overlapped the cross at the center of the screen, and the MEP amplitude was measured. The MEP was recorded in the right first dorsal interosseous muscle. We evaluated the pre-mental practice and post-mental practice motor performance in both groups. As a result, a significant difference was observed in the percentage change of error values between the Real-FB group and the Sham-FB group. Furthermore, the MEP was significantly different between the groups in the 4th and 5th sets. Therefore, it was suggested that TMS-induced MEP-based neurofeedback might enhance the effect of mental practice.
本研究旨在探讨基于经颅磁刺激（TMS）诱发的运动诱发电位（MEP）提供神经反馈是否能增强心理练习（运动想象训练）的效果。24名健康的右利手受试者参与了本研究。受试者被随机分为两组：一组给予正确的TMS反馈（真实反馈组），另一组给予随机的虚假TMS反馈（假反馈组）。当目标圆圈与计算机显示器中心的十字交叉时，受试者想象仅在合适的时机按下开关。在真实反馈组中，根据运动想象前一次试验中测量的MEP幅度向受试者提供反馈。相比之下，假反馈组的受试者得到的反馈值与MEP幅度无关。当从右向左移动的目标与屏幕中心的十字交叉时施加TMS，并测量MEP幅度。在右手第一背侧骨间肌记录MEP。我们评估了两组在心理练习前和心理练习后的运动表现。结果，真实反馈组和假反馈组之间的误差值百分比变化存在显著差异。此外，在第4组和第5组中，两组之间的MEP存在显著差异。因此，提示基于TMS诱发MEP的神经反馈可能增强心理练习的效果。
