Bobkova N V
Institute of Cell Biophysics, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Moscow oblast Russia.
Biochem (Mosc) Suppl Ser A Membr Cell Biol. 2021;15(1):36-51. doi: 10.1134/S1990747821010037. Epub 2021 Feb 21.
The COVID-19 pandemic has swept the world and required the mobilization of scientists and clinicians around the world to combat this serious disease. Along with SARS-CoV-2 virology research, understanding of the fundamental physiological processes, molecular and cellular mechanisms and intracellular signaling pathways underlying the clinical manifestations of COVID-19 is important for effective therapy of this disease. The review describes in detail the interaction of the components of the renin-angiotensin system (RAS) and receptors of end-glycosylated products (RAGE), which plays a special role in normal lung physiology and in pathological conditions in COVID-19, including the development of acute respiratory distress syndrome and "cytokine storm". A separate section is devoted to the latest developments aimed at correcting the dysfunction of the RAS caused by the binding of the virus to angiotensin converting enzyme 2 (ACE2)- the central element of this system. Analysis of published theoretical, clinical, and experimental data indicates the need for a complex treatment to prevent a severe course of COVID-19 using MasR agonists, blockers of the AT1R and NF-κB signaling pathway, as well as compounds with neuroprotective and neuroregenerative effects.
新冠疫情席卷全球，需要动员全世界的科学家和临床医生来对抗这种严重疾病。除了对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的病毒学研究外，了解新冠临床表现背后的基本生理过程、分子和细胞机制以及细胞内信号通路对于有效治疗该疾病至关重要。这篇综述详细描述了肾素-血管紧张素系统（RAS）的组成部分与终末糖基化产物受体（RAGE）之间的相互作用，这在正常肺生理以及新冠的病理状况中发挥着特殊作用，包括急性呼吸窘迫综合征和“细胞因子风暴”的发生。单独的一节专门介绍了旨在纠正由病毒与该系统的核心要素——血管紧张素转换酶2（ACE2）结合所导致的RAS功能障碍的最新进展。对已发表的理论、临床和实验数据的分析表明，需要采用综合治疗方法，使用MasR激动剂、AT1R和NF-κB信号通路阻滞剂以及具有神经保护和神经再生作用的化合物来预防新冠的严重病程。
