de Jonge Kaat, Tillé Laure, Lourenco Joao, Maby-El Hajjami Hélène, Nassiri Sina, Racle Julien, Gfeller David, Delorenzi Mauro, Verdeil Grégory, Baumgaertner Petra, Speiser Daniel E
Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Oncoimmunology. 2021 Feb 2;10(1):1873585. doi: 10.1080/2162402X.2021.1873585.
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.
目前对B细胞在实体瘤患者中的作用了解仍不充分。我们发现，循环B细胞产生肿瘤坏死因子α（TNFα）和/或白细胞介素-6（IL-6），这与接受抗细胞毒性T淋巴细胞相关蛋白4（CTLA4）抗体治疗的黑色素瘤患者的无反应性及总体生存率低有关。对黑色素瘤转移灶中的B细胞进行转录组分析，结果显示炎症反应基因表达丰富。来自肿瘤微环境的公开可用的单个B细胞数据显示，TNFα表达与免疫检查点阻断反应之间呈负相关。这些发现表明，B细胞通过产生炎性细胞因子促进肿瘤生长。这些B细胞可能与三级淋巴结构相关的B细胞不同，后者已被描述为与癌症患者良好的临床结局相关。需要进一步研究来鉴定和表征促进或抑制肿瘤生长的B细胞亚群及其功能，以确定生物标志物和新的治疗靶点。
Zotero 插件
