Astudillo Pablo
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile.
PeerJ. 2021 Feb 17;9:e10869. doi: 10.7717/peerj.10869. eCollection 2021.
To date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is usually regarded as a prototypical non-canonical Wnt ligand, and its expression has been related to cancer progression. On the other hand, YAP/TAZ transcriptional coactivators act in concert with TEAD transcription factors to control gene expression. Although one article has shown previously that is a YAP/TEAD target gene, there is a need for further evidence supporting this regulatory relationship, because a possible YAP/Wnt5a regulatory circuit might have profound implications for cancer biology. This article analyzes publicly available ChIP-Seq, gene expression, and protein expression data to explore this relationship, and shows that might be a YAP/TEAD target gene in several contexts. Moreover, Wnt5a and YAP expression are significantly correlated in specific cancer types, suggesting that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate than previously thought.
迄今为止，大多数关于Wnt信号通路与YAP/TAZ转录共激活因子之间相互作用的数据都集中在该通路的Wnt/β-连环蛋白分支上。相比之下，非经典Wnt通路与YAP/TAZ之间的关系仍有待深入探索。Wnt5a通常被视为典型的非经典Wnt配体，其表达与癌症进展有关。另一方面，YAP/TAZ转录共激活因子与TEAD转录因子协同作用来控制基因表达。尽管之前有一篇文章表明 是一个YAP/TEAD靶基因，但仍需要进一步的证据来支持这种调控关系，因为可能存在的YAP/Wnt5a调控回路可能对癌症生物学具有深远影响。本文分析了公开可用的ChIP-Seq、基因表达和蛋白质表达数据以探索这种关系，并表明 在多种情况下可能是一个YAP/TEAD靶基因。此外，Wnt5a和YAP的表达在特定癌症类型中显著相关，这表明YAP/TAZ与Wnt通路之间的相互作用比之前认为的更为复杂。
