Adekola Hafeez Aderinsayo, Abdullahi Idris Nasir, Emeribe Anthony Uchenna, Faruku Nafiu, Uzairue Leonard, Adeyemi Billyrose Olusoji Matthew, Shuwa Halima Ali
Department of Microbiology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria.
GMS Hyg Infect Control. 2021 Jan 26;16:Doc04. doi: 10.3205/dgkh000375. eCollection 2021.
Nigeria is one of the countries with a high prevalence of measles outbreak in children under 5 years old, despite a history of vaccination. This study aims to determine the prevalence of anti-measles virus IgM and IgG among children under 5 years attending the University of Abuja Teaching Hospital (UATH), Gwagwalada, FCT Abuja, Nigeria. : Whole blood was collected, centrifuged, and serum anti-IgM and anti-IgG against measles virus was analysed using ELISA. Sociodemographic variables and vaccination history of subjects were obtained by interview-based questionnaires. The overall anti-Measles virus IgG and IgM seroprevalences were 29.2% and 14.6%, respectively. The prevalence of measles IgG was significantly associated with the parent's employment status ( =11.67, p=0.008). However, the prevalence of measles virus IgM was significantly associated with children's age ( =16.62, p=0.002), parents' employment status and children's vaccination status ( =7.72, p=0.02). A majority of study participants were not immunised against measles, and a significant number of participants had serological evidence of acute measles virus infection. There is a need for more concerted and massive measles vaccination of children.
尼日利亚是5岁以下儿童麻疹疫情高发的国家之一，尽管该国曾开展过疫苗接种工作。本研究旨在确定在尼日利亚联邦首都区阿布贾夸瓜拉达市阿布贾大学教学医院（UATH）就诊的5岁以下儿童中抗麻疹病毒IgM和IgG的流行情况。采集全血，离心后，采用酶联免疫吸附测定法（ELISA）分析血清中抗麻疹病毒的IgM和IgG。通过基于访谈的问卷获取研究对象的社会人口统计学变量和疫苗接种史。抗麻疹病毒IgG和IgM的总体血清流行率分别为29.2%和14.6%。麻疹IgG的流行率与父母的就业状况显著相关（χ² = 11.67，p = 0.008）。然而，麻疹病毒IgM的流行率与儿童年龄（χ² = 16.62，p = 0.002）、父母就业状况和儿童疫苗接种状况显著相关（χ² = 7.72，p = 0.02）。大多数研究参与者未接种麻疹疫苗，且大量参与者有急性麻疹病毒感染的血清学证据。有必要开展更协调一致且大规模的儿童麻疹疫苗接种工作。
