Acherjya Goutam Kumar, Ali Mohammad, Tarafder Keya, Yeasmin Shamima
Department of of Medicine, Jashore Medical College, Jashore, Bangladesh.
Department of Haematology, National Institute of Cancer Research and Hospital, Mohakhali, Bangladesh.
Indian J Endocrinol Metab. 2020 Nov-Dec;24(6):512-517. doi: 10.4103/ijem.IJEM_312_19. Epub 2021 Jan 12.
Vitamin D has diversity of functions including diabetes mellitus by its anti-inflammatory and immuno-modulatory effects. With the scarcity of the regarding data in Bangladesh, the aim of this study was to assess the relationship between hypovitaminosis D and diabetes mellitus among the postmenopausal women.
An observational study conducted from 1 July to 31 December, 2018 in Jashore, Bangladesh that recruited 152 eligible apparently healthy natural postmenopausal women above 45 years without having any chronic diseases and drugs interfering vitamin D metabolism. Data was taken by face to face interview through self-administered questionnaires. Independent -test, one-way analysis of variance (ANOVA) were used to extract value and Hochberg's post-hoc test used as equal variance assumed in homogeneous sample to evaluate deference between different groups.
Among 152 study subjects, the frequency of diabetes and prediabetes were 28.3% and 31.6%, respectively, among the postmenopausal women by fasting blood sugar level according to the ADA guideline. The study revealed 86 (52.58%) deficient, 56 (36.84%) insufficient, and only 10 (6.58%) sufficient Vitamin D level. Illiterate subjects had less hypovitaminosis D than literate subjects. Urban subjects had more in deficiency state of Vitamin D than rural subjects' on the other hand rural subjects had more insufficiency of Vitamin D. Obese individuals suffered more in hypovitaminosis D than others. There was no significant statically relationship found between FBS and 25(OH)D Level in this study.
With high frequency of diabetes and hypovitaminosis D among the postmenopausal women but there is no statically significant relationship found between diabetes and hypovitaminosis D in this study.
维生素D具有多种功能，包括通过其抗炎和免疫调节作用影响糖尿病。鉴于孟加拉国缺乏相关数据，本研究旨在评估绝经后女性维生素D缺乏与糖尿病之间的关系。
2018年7月1日至12月31日在孟加拉国杰索尔进行了一项观察性研究，招募了152名符合条件的45岁以上明显健康的自然绝经后女性，她们没有任何慢性病且没有药物干扰维生素D代谢。通过自行填写问卷进行面对面访谈获取数据。采用独立样本t检验、单因素方差分析（ANOVA）来提取数值，并在同质样本假设方差齐性的情况下使用霍奇伯格事后检验来评估不同组之间的差异。
在152名研究对象中，根据美国糖尿病协会（ADA）指南，通过空腹血糖水平检测，绝经后女性中糖尿病和糖尿病前期的发生率分别为28.3%和31.6%。研究显示维生素D水平缺乏的有86人（52.58%），不足的有56人（36.84%），充足的仅有10人（6.58%）。文盲受试者的维生素D缺乏情况比有文化的受试者少。城市受试者的维生素D缺乏状态比农村受试者多，而农村受试者的维生素D不足情况更多。肥胖个体的维生素D缺乏情况比其他人更严重。本研究中未发现空腹血糖（FBS）与25（OH）D水平之间存在显著的统计学关系。
绝经后女性中糖尿病和维生素D缺乏的发生率较高，但本研究中未发现糖尿病与维生素D缺乏之间存在统计学上的显著关系。
