Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Via De Crecchio, 4, 80138, Naples, Italy.
Aging Clin Exp Res. 2018 Jun;30(6):625-631. doi: 10.1007/s40520-018-0921-1. Epub 2018 Feb 27.
It has been suggested that overweight and obese individuals have an increased risk to develop vitamin D deficiency, commonly associated with poor muscle performance. The relationship among fat mass, vitamin D status, and skeletal muscle is still debated.
To evaluate the effects of the combination of hypovitaminosis D and overweight on muscle mass and strength, and physical performance in post-menopausal women.
In this cross-sectional study, we recruited post-menopausal women referring to a physiatric outpatient service for the management of osteoporosis over a 36-month period. We compared four groups: (1) normal weight with hypovitaminosis D; (2) overweight with normal serum 25(OH)D; (3) overweight with hypovitaminosis D; and (4) normal weight with normal serum 25(OH)D (control group). Outcome measures were: appendicular lean mass-to-BMI ratio; hand grip strength; and short physical performance battery.
We analysed 368 women (mean aged 67.2 ± 7.8 years): 95 normal weight with hypovitaminosis D, 90 overweight with normal levels of 25(OH)D, 96 overweight with hypovitaminosis D, and 87 normal weight with normal levels of 25(OH)D. Overweight women with hypovitaminosis D had a significant risk of reduced muscle mass (OR 5.70; p < 0.001), strength (OR 12.05; p < 0.001), and performance (OR 5.84; p < 0.001) compared to controls. Normal weight women with hypovitaminosis D had only a greater risk of an impairment of muscle strength (OR 7.30; p < 0.001) and performance (OR 3.16; p < 0.001).
According to our findings, both hypovitaminosis D and overweight should be investigated in post-menopausal women because of their negative effects on skeletal muscle mass and function.
This study demonstrated that hypovitaminosis D is associated to impaired muscle function and its combination with overweight might lead also to muscle wasting in a cohort of post-menopausal women.
有人认为超重和肥胖的人患维生素 D 缺乏症的风险增加，而维生素 D 缺乏症通常与肌肉功能不良有关。脂肪量、维生素 D 状态和骨骼肌之间的关系仍存在争议。
评估维生素 D 缺乏症合并超重对绝经后妇女肌肉质量和力量以及身体机能的影响。
在这项横断面研究中，我们招募了在 36 个月内因骨质疏松症到物理治疗门诊就诊的绝经后妇女。我们比较了四组人群：（1）维生素 D 缺乏症合并正常体重；（2）超重合并正常血清 25（OH）D；（3）超重合并维生素 D 缺乏症；和（4）正常体重合并正常血清 25（OH）D（对照组）。结果测量指标包括：四肢瘦体重与 BMI 比值、手握力和简易体能测试。
我们分析了 368 名女性（平均年龄 67.2±7.8 岁）：95 名维生素 D 缺乏症合并正常体重，90 名超重合并正常 25（OH）D 水平，96 名超重合并维生素 D 缺乏症，87 名正常体重合并正常 25（OH）D 水平。与对照组相比，维生素 D 缺乏症合并超重的女性肌肉质量（OR 5.70；p<0.001）、力量（OR 12.05；p<0.001）和表现（OR 5.84；p<0.001）显著降低的风险更高。维生素 D 缺乏症合并正常体重的女性只有肌肉力量（OR 7.30；p<0.001）和表现（OR 3.16；p<0.001）受损的风险更高。
根据我们的发现，由于维生素 D 缺乏症和超重对骨骼肌肉质量和功能有负面影响，因此应该对绝经后妇女进行调查。
这项研究表明，维生素 D 缺乏症与肌肉功能障碍有关，其与超重相结合可能导致绝经后妇女的肌肉消耗。
