维生素 D 缺乏和超重的结合会影响老年绝经后妇女的肌肉量和功能。

The combination of vitamin D deficiency and overweight affects muscle mass and function in older post-menopausal women.

机构信息

Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Via De Crecchio, 4, 80138, Naples, Italy.

出版信息

Aging Clin Exp Res. 2018 Jun;30(6):625-631. doi: 10.1007/s40520-018-0921-1. Epub 2018 Feb 27.

DOI:10.1007/s40520-018-0921-1

PMID:29488185

Abstract

BACKGROUND

It has been suggested that overweight and obese individuals have an increased risk to develop vitamin D deficiency, commonly associated with poor muscle performance. The relationship among fat mass, vitamin D status, and skeletal muscle is still debated.

AIMS

To evaluate the effects of the combination of hypovitaminosis D and overweight on muscle mass and strength, and physical performance in post-menopausal women.

METHODS

In this cross-sectional study, we recruited post-menopausal women referring to a physiatric outpatient service for the management of osteoporosis over a 36-month period. We compared four groups: (1) normal weight with hypovitaminosis D; (2) overweight with normal serum 25(OH)D; (3) overweight with hypovitaminosis D; and (4) normal weight with normal serum 25(OH)D (control group). Outcome measures were: appendicular lean mass-to-BMI ratio; hand grip strength; and short physical performance battery.

RESULTS

We analysed 368 women (mean aged 67.2 ± 7.8 years): 95 normal weight with hypovitaminosis D, 90 overweight with normal levels of 25(OH)D, 96 overweight with hypovitaminosis D, and 87 normal weight with normal levels of 25(OH)D. Overweight women with hypovitaminosis D had a significant risk of reduced muscle mass (OR 5.70; p < 0.001), strength (OR 12.05; p < 0.001), and performance (OR 5.84; p < 0.001) compared to controls. Normal weight women with hypovitaminosis D had only a greater risk of an impairment of muscle strength (OR 7.30; p < 0.001) and performance (OR 3.16; p < 0.001).

DISCUSSION

According to our findings, both hypovitaminosis D and overweight should be investigated in post-menopausal women because of their negative effects on skeletal muscle mass and function.

CONCLUSIONS

This study demonstrated that hypovitaminosis D is associated to impaired muscle function and its combination with overweight might lead also to muscle wasting in a cohort of post-menopausal women.

摘要

背景

有人认为超重和肥胖的人患维生素 D 缺乏症的风险增加，而维生素 D 缺乏症通常与肌肉功能不良有关。脂肪量、维生素 D 状态和骨骼肌之间的关系仍存在争议。

目的

评估维生素 D 缺乏症合并超重对绝经后妇女肌肉质量和力量以及身体机能的影响。

方法

在这项横断面研究中，我们招募了在 36 个月内因骨质疏松症到物理治疗门诊就诊的绝经后妇女。我们比较了四组人群：（1）维生素 D 缺乏症合并正常体重；（2）超重合并正常血清 25（OH）D；（3）超重合并维生素 D 缺乏症；和（4）正常体重合并正常血清 25（OH）D（对照组）。结果测量指标包括：四肢瘦体重与 BMI 比值、手握力和简易体能测试。

结果

我们分析了 368 名女性（平均年龄 67.2±7.8 岁）：95 名维生素 D 缺乏症合并正常体重，90 名超重合并正常 25（OH）D 水平，96 名超重合并维生素 D 缺乏症，87 名正常体重合并正常 25（OH）D 水平。与对照组相比，维生素 D 缺乏症合并超重的女性肌肉质量（OR 5.70；p<0.001）、力量（OR 12.05；p<0.001）和表现（OR 5.84；p<0.001）显著降低的风险更高。维生素 D 缺乏症合并正常体重的女性只有肌肉力量（OR 7.30；p<0.001）和表现（OR 3.16；p<0.001）受损的风险更高。