Clarke S D, Benjamin L, Bell L, Phinney S D
Graduate Program of Nutrition, University of Minnesota, St Paul.
Am J Clin Nutr. 1988 May;47(5):828-35. doi: 10.1093/ajcn/47.5.828.
The objective was to determine if dietary fish oil decreased the degree of fatty acid saturation in rat lung phosphatidylcholine (PC). A diet containing 12% of its energy as fat was fed for 3 wk to growing male Sprague-Dawley rats (trial I) or to pregnant rats for days 8-21 of gestation (trial II). The dietary fat treatments in trial I were safflower oil (SO), menhaden oil (MO), or hydrogenated coconut oil (HCO) and in trial II were SO, MO, HCO, or SO-MO (75%:25%). Polyunsaturated fatty acids reduced (p less than 0.05) hepatic fatty acid synthetase (MO greater than SO) in growing rats but the dietary lipids had no effect on lung palmitate content. Maternal consumption of MO vs SO reduced (p less than 0.05) fetal body weight and lung weight but not lung:body wt ratio. Dietary MO and SO-MO increased (p less than 0.05) disaturated PC content of fetal lungs. The fetal lung data indicate that maternal ingestion of fish oil improve fetal lung maturation.
目的是确定日粮中的鱼油是否会降低大鼠肺磷脂酰胆碱（PC）中脂肪酸的饱和程度。将含12%能量来自脂肪的日粮喂养生长中的雄性斯普拉格-道利大鼠3周（试验I），或在妊娠第8至21天喂养怀孕大鼠（试验II）。试验I中的日粮脂肪处理组为红花油（SO）、鲱鱼油（MO）或氢化椰子油（HCO），试验II中的日粮脂肪处理组为SO、MO、HCO或SO-MO（75%:25%）。多不饱和脂肪酸可降低（p<0.05）生长中大鼠肝脏脂肪酸合成酶水平（MO>SO），但日粮脂质对肺棕榈酸含量无影响。与摄入SO相比，母体摄入MO可降低（p<0.05）胎儿体重和肺重量，但不影响肺与体重的比值。日粮中的MO和SO-MO可增加（p<0.05）胎儿肺中双饱和PC的含量。胎儿肺的数据表明，母体摄入鱼油可促进胎儿肺成熟。
