Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
J Alzheimers Dis. 2016;51(4):1175-82. doi: 10.3233/JAD-150920.
Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI).
To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly.
A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China. The Chinese version of the Mini-Mental Status Examination (C-MMSE) was used to screen subjects with MCI. Associations of MetS with its individual or combined components and MCI were analyzed using conditional regression analyses with or without adjustment for gender, education, current smoking, current drinking, and physical activities.
There were 379 subjects with MCI and 379 gender- and age-matched healthy controls in the study. Compared with healthy controls in univariate analyses, subjects with MCI were more likely to have less time spent on physical activity, lower C-MMSE score, heavier weight, larger waistline and hipline, higher diastolic blood pressure, higher body mass index, higher abdominal obesity index, higher serum glycated hemoglobin, higher serum triglycerides, higher serum cholesterol, higher serum uric acid, and higher serum alanine aminotransferase. After multivariable adjustment, MetS was significantly associated with an increased risk of MCI (OR = 2.277; 95% CI: 1.086-4.773). Among MetS components, abdominal obesity (OR = 2.101; 95% CI: 1.224-3.608) and hypertension (OR = 2.075; 95% CI: 1.170-3.678) showed a significant association with MCI, respectively; while these two components were combined, the association was stronger (OR = 2.459; 95% CI: 1.360-4.447).
MetS and its components, particularly abdominal obesity and hypertension, were found to be significantly associated with the risk of MCI.
代谢综合征（MetS）可能与轻度认知障碍（MCI）有关。
探讨代谢综合征及其各组成部分与老年人 MCI 的关系。
采用病例对照研究，对中国上海西南郊区社区内年龄在 65 岁及以上的老年人进行研究。采用中文版简易精神状态检查（C-MMSE）筛查 MCI 患者。采用条件回归分析，分别在调整和不调整性别、教育程度、当前吸烟、当前饮酒和身体活动的情况下，分析代谢综合征及其各组成部分与 MCI 的关系。
本研究共纳入 379 例 MCI 患者和 379 名性别和年龄匹配的健康对照者。与单因素分析中健康对照组相比，MCI 患者体力活动时间较少、C-MMSE 评分较低、体重较重、腰围和臀围较大、舒张压较高、体质指数较高、腹部肥胖指数较高、糖化血红蛋白较高、血清甘油三酯较高、血清胆固醇较高、血清尿酸较高、血清丙氨酸氨基转移酶较高。经多变量调整后，代谢综合征与 MCI 的发生风险显著相关（OR=2.277；95%CI：1.086-4.773）。在代谢综合征各组分中，腹部肥胖（OR=2.101；95%CI：1.224-3.608）和高血压（OR=2.075；95%CI：1.170-3.678）与 MCI 显著相关；而这两个组分合并时，相关性更强（OR=2.459；95%CI：1.360-4.447）。
代谢综合征及其各组成部分，尤其是腹部肥胖和高血压，与 MCI 的发生风险显著相关。
