Memory Clinic, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Institute of Biomedical Sciences-Morphological Sciences Program, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
PLoS One. 2018 Mar 26;13(3):e0194990. doi: 10.1371/journal.pone.0194990. eCollection 2018.
Metabolic Syndrome (MetS) refers to a cluster of metabolic disturbances which is associated with increased risk for vascular and degenerative conditions in general population. Although the relationship between vascular risk factors and dementia is undisputable, additional hazard for cognitive decline in older population with concurrent metabolic disorders still waits to be demonstrated. The present review aims to analyze data on MetS and risk for cognitive decline in elderly persons.
Database searches were performed in Medline, ISI and PsycINFO for articles assessing cognitive performances of older subjects with MetS.
Of a total of 505 studies, 25 were selected for the review. Risk of selection biases was identified in all the studies. Although all articles followed recognized diagnostic recommendations for MetS, minor criteria modifications were detected in most of them. Hyperglycemia was consistently associated with impaired cognitive performances in older individuals, but the role of MetS for cognitive decline and for the onset of dementia showed heterogeneous results.
Current available data in the literature concerning the impact of MetS on the cognition of older population is inconclusive and based on inconsistent evidence. Differential effects of individual MetS components and factors associated with the age of the sample may have accounted for divergent findings among articles, but larger and higher quality studies in this field are still needed.
代谢综合征（MetS）是指一组代谢紊乱，与一般人群中血管和退行性疾病的风险增加有关。尽管血管危险因素与痴呆之间的关系是无可争议的，但在伴有代谢紊乱的老年人群中，认知能力下降的额外风险仍有待证明。本综述旨在分析代谢综合征与老年人认知能力下降风险的数据。
在 Medline、ISI 和 PsycINFO 数据库中对评估代谢综合征老年人认知表现的文章进行了检索。
在总共 505 项研究中，选择了 25 项进行综述。所有研究都存在选择偏倚的风险，尽管所有文章都遵循了公认的代谢综合征诊断建议，但大多数文章都对次要标准进行了修改。高血糖与老年人认知功能受损始终相关，但代谢综合征对认知能力下降和痴呆发病的作用结果存在差异。
目前文献中关于代谢综合征对老年人群认知的影响的现有数据尚无定论，且证据不一致。个体代谢综合征成分和与样本年龄相关的因素的不同影响可能导致了文章之间的分歧发现，但该领域仍需要更大规模和更高质量的研究。
