（福斯克）波伊尔（）；水叶提取物的酚类成分及其抗炎、镇痛活性评价。
(Forssk.) Poir. (); phenolic constituents of the aqueous leaves extract and evaluation of its anti-inflammatory, analgesic activities.
作者信息
Emam Mahmoud, Moustafa Passant E, Elkhateeb Ahmed, Hussein Sameh R, Marzouk Mona M, Abd El-Rahman Sahar S, Abdel-Hameed El-Sayed S, Abdel-Rahman Rehab F
机构信息
College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza P. O. 12622, Egypt.
出版信息
Heliyon. 2021 Feb 13;7(2):e06205. doi: 10.1016/j.heliyon.2021.e06205. eCollection 2021 Feb.
BACKGROUND
The plant kingdom is considered one of the most common sources for structural and biological diversity. In particular, the wild category acquires our attention to investigate the phytochemical and the biological evaluations.
METHODS
was exposed to phytochemical examination using HPLC-ESI-MS analysis. Furthermore, the anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, whereas both the central and peripheral analgesic activities were tested via hot plate test in rats and acetic acid-induced writhing in mice, respectively.
RESULTS
Twenty phenolic compounds of aqueous leaves extract were emphasized by liquid chromatography coupled with mass spectrometry. Moreover, exhibited both anti-inflammatory and peripheral analgesic activities. Furthermore, significantly decreased the immune expression of MMP-9, TNF-α and TGF-β1 in the hind paw of rats.
CONCLUSION
possess peripheral anti-nociceptive and anti-inflammatory effects in rats mediated through its anti-oxidant and anti-inflammatory activities. The activity of leaves extract might be attributed to the presence of hydroxy and keto structures.
背景
植物界被认为是结构和生物多样性最常见的来源之一。特别是，野生植物类别引起了我们对其进行植物化学和生物学评估的关注。
方法
使用高效液相色谱-电喷雾电离质谱分析对其进行植物化学检查。此外，使用角叉菜胶诱导的大鼠足肿胀模型评估抗炎活性，而分别通过大鼠热板试验和小鼠醋酸诱导的扭体试验测试中枢和外周镇痛活性。
结果
液相色谱-质谱联用技术鉴定出水叶提取物中的20种酚类化合物。此外，其具有抗炎和外周镇痛活性。此外，其显著降低了大鼠后爪中基质金属蛋白酶-9、肿瘤坏死因子-α和转化生长因子-β1的免疫表达。
结论
其通过抗氧化和抗炎活性在大鼠中具有外周抗伤害感受和抗炎作用。叶提取物的活性可能归因于羟基和酮结构的存在。
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