棉叶豆（Hook.）D. Dietr. 中一种新的多氧化黄酮醇棉子糖-3---d-槐糖苷及其叶甲醇提取物的体内保肝、抗炎和抗溃疡活性
A New Polyoxygenated Flavonol Gossypetin-3---d-Robinobioside from (Hook.) D. Dietr. and In Vivo Hepatoprotective, Anti-Inflammatory, and Anti-Ulcer Activities of the Leaf Methanol Extract.
机构信息
Department of Phytochemistry and Plant Systematics, National Research Centre, Dokki, Cairo 12622, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Cairo 12566, Egypt.
出版信息
Molecules. 2018 Dec 31;24(1):138. doi: 10.3390/molecules24010138.
A hitherto unknown polyoxygenated flavonol robinobioside (gossypetin-3---d-robinobioside) was isolated from the leaves of along with thirteen known phenolic secondary metabolites. The isolated compounds were characterized using spectroscopic analysis, including 1D and 2D NMR and mass spectrometry (MS) analyses. The extract reduced the level of liver damage in CCl₄-induced liver injury in rats. A decrease of the liver biomarkers-aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and an increase of total antioxidant capacity (TAC) levels-were observed similar to the liver protecting drug silymarin. In addition, the extract showed promising activity against carrageenan-induced paw edema in rats and protected their stomachs against ethanol-induced gastric ulcers in a concentration dependent fashion. The observed activities could be attributed to the high content of antioxidant polyphenols. Our results suggest that the has the capacity to scavenge free radicals and can protect against oxidative stress, and liver and stomach injury.
一种 hitherto 未知的多氧化黄酮醇罗宾糖苷（gossypetin-3---d-robinobioside）与十三种已知的酚类次生代谢物一起从叶子中分离出来。使用光谱分析，包括 1D 和 2D NMR 和质谱 (MS) 分析对分离出的化合物进行了表征。提取物降低了 CCl₄诱导的大鼠肝损伤中肝损伤的水平。观察到肝生物标志物天冬氨酸氨基转移酶 (AST) 和丙氨酸氨基转移酶 (ALT) 的降低以及总抗氧化能力 (TAC) 水平的升高，与肝保护药物水飞蓟素相似。此外，提取物对大鼠角叉菜胶诱导的足肿胀表现出有希望的活性，并以浓度依赖的方式保护其胃免受乙醇诱导的胃溃疡。观察到的活性可归因于高含量的抗氧化多酚。我们的结果表明，具有清除自由基的能力，可以防止氧化应激以及肝和胃损伤。
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