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在彼此相隔一年内开展的成对独立全国代表性疫苗接种覆盖率调查:2000 - 2019年全球概述

Pairs of independent nationally representative vaccination coverage surveys conducted within one year of each other: A global overview covering 2000-2019.

作者信息

Brown David W, Danovaro-Holliday M Carolina, Rhoda Dale A

机构信息

BCGI LLC/pivot-23.5°, Cornelius, NC, USA.

World Health Organization, Geneva, Switzerland.

出版信息

Vaccine X. 2021 Jan 29;7:100085. doi: 10.1016/j.jvacx.2021.100085. eCollection 2021 Apr.

Abstract

BACKGROUND

Population-based surveys play an important role in measuring vaccination coverage. Surveys measuring vaccination coverage may be commissioned by the Expanded Programme on Immunization (EPI surveys) or part of multi-domain non-EPI surveys such as Demographic and Health Surveys (DHS) or Multiple Indicator Cluster Surveys (MICS). Surveys conducted too close in time to each other may not only be an inefficient use of resources but may also create problems for programme staff when results suggest inconsistent patterns of programme performance for similar time periods.

OBJECTIVE

To summarize the occurrence of vaccination coverage surveys conducted close in time during 2000-2019 and compare results of EPI and non-EPI coverage surveys when the surveys were conducted within one year of each other.

METHODS

Using a database of published national-level vaccination coverage survey results compiled by the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF), the authors abstracted information on survey field work dates, sample size, percentage of children with documented history of vaccination and the percent coverage, as well as published uncertainty intervals from DHS and MICS, for the first and third doses of diphtheria-tetanus toxoid-pertussis containing vaccine (DTP1, DTP3) and first dose of measles containing vaccine (MCV1). Survey results of EPI and non-EPI surveys were compared.

RESULTS

The authors identified 646 surveys with final reports and estimates of national-level vaccination coverage for DTP1, DTP3, or MCV1 from a total of 687 surveys with data collection start date from 2000 to 2019. Of the 140 countries with at least one vaccination coverage survey, a median of four surveys was observed. Most countries were Gavi-eligible and located in the WHO Africa Region. Sixty-six survey dyads were identified where an EPI survey occurred within one year of a non-EPI survey. For the 66 dyads, in 49 of 59 with information available, EPI surveys reported higher proportion of documented evidence of vaccination and EPI survey results tended to suggest higher levels of vaccination coverage compared to the non-EPI surveys; quite often, differences were substantial. Surveys that found higher proportions of children with documented vaccination evidence tended to also find higher proportions of children who had been vaccinated.

SUMMARY

Opportunities exist to improve overall planning of vaccination coverage measurement in population-based household surveys so that both EPI and non-EPI surveys are more comparable and survey coverage estimates are more appropriately spaced in time. When surveys occur too close in time, careful attention is warranted to ensure comparability and assess sources of documented evidence of vaccination and related coverage differences.

摘要

背景

基于人群的调查在衡量疫苗接种覆盖率方面发挥着重要作用。衡量疫苗接种覆盖率的调查可能由扩大免疫规划(EPI调查)委托开展,或者是多领域非EPI调查的一部分,如人口与健康调查(DHS)或多指标类集调查(MICS)。在时间上过于接近的调查不仅可能导致资源利用效率低下,而且当结果显示相似时间段内项目执行情况存在不一致模式时,还可能给项目工作人员带来问题。

目的

总结2000年至2019年期间在时间上接近开展的疫苗接种覆盖率调查的情况,并比较在彼此相隔一年内开展的EPI和非EPI覆盖率调查的结果。

方法

作者利用世界卫生组织(WHO)和联合国儿童基金会(UNICEF)汇编的已发表的国家级疫苗接种覆盖率调查结果数据库,提取关于调查现场工作日期、样本量、有疫苗接种记录历史的儿童百分比和覆盖率,以及来自DHS和MICS的已发表的不确定性区间等信息,涉及白喉-破伤风类毒素-百日咳联合疫苗(DTP1、DTP3)的第一剂和第三剂以及含麻疹疫苗(MCV1)的第一剂。比较了EPI和非EPI调查的结果。

结果

作者从2000年至2019年数据收集开始日期的687项调查中,确定了646项有最终报告和国家级DTP1、DTP3或MCV1疫苗接种覆盖率估计值的调查。在至少进行过一次疫苗接种覆盖率调查的140个国家中,观察到的调查中位数为4次。大多数国家符合全球疫苗免疫联盟(Gavi)资助条件,且位于WHO非洲区域。确定了66组调查二元组,其中EPI调查在非EPI调查的一年内进行。对于这66组二元组,在59组有可用信息的二元组中,有49组EPI调查报告的有疫苗接种记录证据的比例更高,并且与非EPI调查相比,EPI调查结果往往显示更高的疫苗接种覆盖率水平;差异通常很大。发现有疫苗接种记录证据的儿童比例较高的调查,往往也发现接种过疫苗的儿童比例较高。

总结

在基于人群的家庭调查中,存在改进疫苗接种覆盖率测量总体计划的机会,以便使EPI和非EPI调查更具可比性,并且调查覆盖率估计值在时间上的间隔更合适。当调查在时间上过于接近时,需要仔细关注以确保可比性,并评估疫苗接种记录证据的来源以及相关的覆盖率差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e83/7887424/898b4012f9a0/gr1.jpg

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