Zhang Qiao, Chen Yan-Yan, Yue Shi-Jun, Wang Wen-Xiao, Zhang Li, Tang Yu-Ping
Engineering Technology Research Center of Shaanxi Administration of Chinese Herbal Pieces, Shaanxi University of Chinese Medicine Xianyang 712046, China.
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xianyang 712046, China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(3):539-551. doi: 10.19540/j.cnki.cjcmm.20201105.601.
Rhei Radix et Rhizoma(RRR) is a commonly used traditional Chinese medicine, with extensive pharmacological effects and clinical applications. This paper summarized processing history evolution of RRR and its effect on chemical compositions and pharmacological effects, and provided feasible insights for further studies on the chemical compositions and pharmacological effects of RRR before and after processing. Relevant information demonstrated that RRR has a long history of processing and various methods. At pre-sent, Chinese Pharmacopoeia mainly records four processing methods: cleaning(raw RRR), wine processing(RRR stir-fried with wine), steaming processing(RRR wine steaming), fried charcoal(RRR charring). RRR has a good effect in clearing heat effect, hemostatic effect and blood promoting effect, and its main chemical components are anthraquinone/anthrones, stilbene, phenylbutanone, chromogens, flavonoids and tannin compounds. This paper reviewed the history evolution of RRR and its effect on chemical composition and pharmacological changes, and put forward further study ideas, with the aim to provide a basic reference for processing mechanism, effective material basis and clinical application of RRR.
大黄是一种常用的传统中药，具有广泛的药理作用和临床应用。本文综述了大黄炮制历史沿革及其对化学成分和药理作用的影响，为进一步研究大黄炮制前后的化学成分和药理作用提供了可行的思路。相关资料表明，大黄的炮制历史悠久，方法多样。目前，《中国药典》主要记载了四种炮制方法：净制（生大黄）、酒制（酒炙大黄）、蒸制（酒蒸大黄）、炒炭（炒炭大黄）。大黄在清热、止血、活血方面疗效显著，其主要化学成分有蒽醌/蒽酮、二苯乙烯、苯丁酮、色原酮、黄酮类及鞣质类化合物。本文回顾了大黄炮制历史沿革及其对化学成分和药理变化的影响，并提出了进一步的研究思路，旨在为大黄的炮制机理、有效物质基础及临床应用提供基础参考。
