Chen Qi-Yan, Fu Chao-Mei, Luo Rui-Feng, Lin Mei-Si, Liao Wan, Gao Fei
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Resources in Southwestern China Chengdu 611137, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Resources in Southwestern China Chengdu 611137, China Sichuan Provincial Acupuncture School Chengdu 611731, China.
Zhongguo Zhong Yao Za Zhi. 2021 Jan;46(1):15-23. doi: 10.19540/j.cnki.cjcmm.20201012.601.
Rhei Radix et Rhizoma was first recorded in Shennong Ben Cao Jing, with a wide range of pharmacological activities. Autoimmune disease is a kind of disease that damages the tissue structure and function of immune cells and their components due to the impairment of immune tolerance function, including atherosclerosis, multiple sclerosis, gout, rheumatoid arthritis, autoimmune thyroiditis, ulcerative colitis, type 1 diabetes and IgA nephropathy. In recent years, clinical and experimental studies show that Rhei Radix et Rhizoma has potential therapeutic effects on autoimmune diseases. Under the guidance of the theory of traditional Chinese medicine, this paper reviews therapeutic and intervening effects of Rhei Radix et Rhizoma and its main active ingredient anthraquinone on autoimmune diseases. It also puts forward new study directions in view of the existing problems in studies of rhubarb and its anthraquinone, with the aim to provide reference for clinical treatment and scientific studies of effect of Rhei Radix et Rhizomaon autoimmune diseases.
大黄最早记载于《神农本草经》，具有广泛的药理活性。自身免疫性疾病是一类由于免疫耐受功能受损而损害免疫细胞及其成分的组织结构和功能的疾病，包括动脉粥样硬化、多发性硬化症、痛风、类风湿性关节炎、自身免疫性甲状腺炎、溃疡性结肠炎、1型糖尿病和IgA肾病。近年来，临床和实验研究表明，大黄对自身免疫性疾病具有潜在的治疗作用。本文在中医理论指导下，综述了大黄及其主要活性成分蒽醌对自身免疫性疾病的治疗和干预作用。并针对大黄及其蒽醌研究中存在的问题提出了新的研究方向，旨在为大黄治疗自身免疫性疾病的临床治疗和科学研究提供参考。
