Department of Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
J Coll Physicians Surg Pak. 2021 Feb;31(2):166-170. doi: 10.29271/jcpsp.2021.02.166.
To determine the characteristics and prognosis of brain metastasised HER-2 positive breast cancer (BC) patients.
Descriptive study.
Ankara Oncology Training and Research Hospital, Turkey between 2000 and 2019.
HER-2 positive BC patients were analysed retrospectively and 105 patients were included in the study. Age 18 years and over, HER-2 positive BC, with BM (brain metastases) were the inclusion criteria. Patients with secondary malignancies, those with missing data, and irregular follow-up were excluded from the study. The age, type of treatment, Eastern Cooperative Oncology Group Performance Status (ECOG PS) score, BM date, and the last contact date of the patients were obtained from the hospital records. The Kaplan-Meier method was used to determine the time to BM and OS. Independent factors affecting OS and time to BM were determined using the Cox regression model.
Patients with ECOG PS score of 0-1 at the time of the BM had 19 months median overall survival (OS), while patients with ECOG PS score of 2 had 8 months (p <0.01). Median OS after BM was 32 and 14 months for patients with one BM and patients with multiple BM, respectively (p <0.01). Multivariate cox regression analyses revealed that time to progression of BM was shorter in patients with high-grade tumors compared to patients with low-grade tumors (p= 0.048), and in patients with de-novo metastasis compared to patients without de-novo metastasis (p= 0.003). Conclusıon: Tumor grade and de-novo metastasis (extracranial metastasis at the time of diagnosis) are independent predictive factors that may cause the earlier occurrence of BM and affect mortality in BC patients. Key Words: Brain metastasis, Breast cancer, HER-2 positive, Metastasis.
确定 HER-2 阳性乳腺癌（BC）脑转移患者的特征和预后。
描述性研究。
土耳其安卡拉肿瘤培训与研究医院，2000 年至 2019 年。
回顾性分析 HER-2 阳性 BC 患者，共纳入 105 例患者。纳入标准为年龄≥18 岁，HER-2 阳性 BC，有 BM（脑转移）。排除标准为有第二原发恶性肿瘤、资料缺失、随访不规律的患者。从医院病历中获取患者的年龄、治疗类型、东部肿瘤协作组体能状态（ECOG PS）评分、BM 日期和最后联系日期。采用 Kaplan-Meier 法确定 BM 和 OS 时间。采用 Cox 回归模型确定影响 OS 和 BM 时间的独立因素。
BM 时 ECOG PS 评分为 0-1 的患者中位总生存期（OS）为 19 个月，ECOG PS 评分为 2 的患者为 8 个月（p<0.01）。有 1 个 BM 和多个 BM 的患者 BM 后 OS 中位数分别为 32 个月和 14 个月（p<0.01）。多因素 Cox 回归分析显示，与低级别肿瘤患者相比，高级别肿瘤患者的 BM 进展时间更短（p=0.048），与无初发转移患者相比，有初发转移患者的 BM 进展时间更短（p=0.003）。结论：肿瘤分级和初发转移（诊断时的颅外转移）是可能导致 BM 更早发生并影响 BC 患者死亡率的独立预测因素。关键词：脑转移；乳腺癌；HER-2 阳性；转移。
