Karadag Ibrahim, Karakaya Serdar, Akkan Tolga, Demir Bilgin, Alkurt Ertugrul Gazi, Dogan Mutlu
Department of Medical Oncology, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey.
Department of Medical Oncology, Health Science University, Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.
Cancer Manag Res. 2023 Mar 23;15:311-317. doi: 10.2147/CMAR.S403445. eCollection 2023.
We aimed to investigate the prognostic significance of insulin resistance (IR) markers fasting triglyceride-glucose (TyG) index and triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio in HER2-positive breast cancer (BC) patients with brain metastasis (BM).
In this single-center study, 120 patients who met the criteria were included. TyG and TG/HDL-C at the time of diagnosis were computed retrospectively. For TyG and TG/HDL-C, the median values of 9.32 and 2.95 were taken as the cut-off, respectively. TyG values <9.32 and <2.95 were considered low, and TG/HDL-C values ≥9.32 and ≥2.95 were considered high.
The median overall survival (OS) was 47 months (95% CI: 40.54-53.45). Time to BM was 22 months (95% CI: 17.22-26.73). The median time to BM was 35 months (95% CI: 20.90-49.09) in the low TyG group and 15 months (95% CI: 8.92-21.07) in the high TyG group ( < 0.001). The time to BM was 27 months (95% CI: 20.49-33.50) in the low TG/HDL-C group and 20 months (95% CI: 16.76-23.23) in the high TG/HDL-C group (=0.084). In the multivariate Cox regression analysis, the TyG index (HR: 20.98, 95% CI: 7.14-61.59, < 0.001) was an independent risk factor for time to BM.
These findings suggest that the TyG index could be used as a predictive biomarker at the time of diagnosis for risk of time BM in patients with HER2-positive BC. The TyG index can be used as a standard potential marker with prospective studies confirming these data.
我们旨在研究胰岛素抵抗（IR）标志物空腹甘油三酯-葡萄糖（TyG）指数和甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）在HER2阳性乳腺癌（BC）脑转移（BM）患者中的预后意义。
在这项单中心研究中，纳入了120例符合标准的患者。回顾性计算诊断时的TyG和TG/HDL-C。对于TyG和TG/HDL-C，分别将中位数9.32和2.95作为临界值。TyG值<9.32和<2.95被视为低，TG/HDL-C值≥9.32和≥2.95被视为高。
中位总生存期（OS）为47个月（95%CI：40.54 - 53.45）。发生BM的时间为22个月（95%CI：17.22 - 26.73）。低TyG组发生BM的中位时间为35个月（95%CI：20.90 - 49.09），高TyG组为15个月（95%CI：8.92 - 21.07）（P<0.001）。低TG/HDL-C组发生BM的时间为27个月（95%CI：20.49 - 33.50），高TG/HDL-C组为20个月（95%CI：16.76 - 23.23）（P = 0.084）。在多因素Cox回归分析中，TyG指数（HR：20.98，95%CI：7.14 - 61.59，P<0.001）是发生BM时间的独立危险因素。
这些发现表明，TyG指数可作为HER2阳性BC患者诊断时发生BM风险的预测生物标志物。TyG指数可作为一种标准的潜在标志物，有待前瞻性研究证实这些数据。
