Terr L I, Linthicum F H, House W F
House Ear Institute, Los Angeles, California.
Am J Otol. 1988 Jan;9(1):1-7.
This report provides histologic data on the cochlear nuclei of a patient who used a cochlear implant in the right ear for about 10 years and in the left ear for about 1 year. The most pronounced abnormality in the cochlear nuclei is sites of gliosis. However, since areas of necrosis with similar size, shape, and content of cells were observed outside the nuclei, the gliosis was not specific to the nuclei. There were no other unusual changes in the cochlear nuclei, such as excessive chromatolysis, excessive accumulation of lipofuscin, swollen neurons, or accumulation of glial cells. Comparison showed no statistically significant differences in sizes of cell bodies, size of nuclei, and total density of neurons in cochlear nuclei between the right and left sides. However, the density of normal-looking neurons (with visible nucleoli and without visible pathologic features) was noticeably less on the longer-stimulated side. Some differences between the longer- and shorter-stimulated sides may be due to differences before implantation or other factors, as well as to effects of stimulation.
本报告提供了一名患者耳蜗核的组织学数据，该患者右耳使用人工耳蜗约10年，左耳使用约1年。耳蜗核中最明显的异常是胶质增生部位。然而，由于在核外观察到了大小、形状和细胞内容物相似的坏死区域，因此这种胶质增生并非耳蜗核所特有。耳蜗核没有其他异常变化，如过度的染色质溶解、脂褐素过度积累、神经元肿胀或胶质细胞积聚。比较显示，左右两侧耳蜗核的细胞体大小、核大小和神经元总密度在统计学上没有显著差异。然而，在受刺激时间较长的一侧，外观正常的神经元（有可见核仁且无可见病理特征）密度明显较低。受刺激时间较长和较短的两侧之间的一些差异可能是由于植入前的差异或其他因素，以及刺激的影响。
