Stein Timothy J, Pellin Mackenzie, Steinberg Howard, Chun Ruthanne
Departments of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA.
J Am Anim Hosp Assoc. 2010 Nov-Dec;46(6):413-7. doi: 10.5326/0460413.
Gastrointestinal (GI) lymphoma is the most frequently diagnosed form of lymphoma in the cat and is categorized into two distinct forms based on the size of neoplastic lymphocytes. Treatments for both large- and small-cell GI lymphoma have been described previously; however, multiple chemotherapy protocols were used, a minimal amount of histopathological characterization was provided, and, in most studies, the majority of diagnoses were obtained via endoscopic pinch biopsies. Twenty-eight cats (24 with full-thickness intestinal biopsies) were diagnosed with small-cell GI lymphoma and treated with a combination of chlorambucil and glucocorticoids. The majority of cases were strongly CD3+, and many displayed epitheliotropism. The overall clinical response rate was 96%, with a median clinical remission duration of 786 days. Follow-up identified seven cats with relapsed disease-all of which were treated with a rescue protocol of cyclophosphamide and glucocorticoids; the response rate was 100%, and four of the 28 cats were diagnosed with a second malignancy.
胃肠道（GI）淋巴瘤是猫最常被诊断出的淋巴瘤形式，根据肿瘤性淋巴细胞的大小可分为两种不同形式。此前已描述了大细胞和小细胞GI淋巴瘤的治疗方法；然而，使用了多种化疗方案，提供的组织病理学特征最少，并且在大多数研究中，大多数诊断是通过内镜钳取活检获得的。28只猫（24只进行了全层肠道活检）被诊断为小细胞GI淋巴瘤，并接受了苯丁酸氮芥和糖皮质激素联合治疗。大多数病例CD3呈强阳性，许多表现为亲上皮性。总体临床缓解率为96%，中位临床缓解持续时间为786天。随访发现7只猫疾病复发——所有这些猫均接受了环磷酰胺和糖皮质激素的挽救方案治疗；缓解率为100%，28只猫中有4只被诊断出患有第二种恶性肿瘤。
