MemTrax 记忆测验与蒙特利尔认知评估在检测中国人群阿尔茨海默病所致轻度认知障碍和痴呆中的有效性比较。

Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort.

机构信息

Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Yunnan Provincial Clinical Research Center for Neurological Diseases, Yunnan, China.

出版信息

J Alzheimers Dis. 2021;80(3):1257-1267. doi: 10.3233/JAD-200936.

DOI:10.3233/JAD-200936

PMID:33646151

Abstract

BACKGROUND

A valid, reliable, accessible, engaging, and affordable digital cognitive screen instrument for clinical use is in urgent demand.

OBJECTIVE

To assess the clinical utility of the MemTrax memory test for early detection of cognitive impairment in a Chinese cohort.

METHODS

The 2.5-minute MemTrax and the Montreal Cognitive Assessment (MoCA) were performed by 50 clinically diagnosed cognitively normal (CON), 50 mild cognitive impairment due to AD (MCI-AD), and 50 Alzheimer's disease (AD) volunteer participants. The percentage of correct responses (MTx-% C), the mean response time (MTx-RT), and the composite scores (MTx-Cp) of MemTrax and the MoCA scores were comparatively analyzed and receiver operating characteristic (ROC) curves generated.

RESULTS

Multivariate linear regression analyses indicated MTx-% C, MTx-Cp, and the MoCA score were significantly lower in MCI-AD versus CON and in AD versus MCI-AD groups (all with p≤0.001). For the differentiation of MCI-AD from CON, an optimized MTx-% C cutoff of 81% had 72% sensitivity and 84% specificity with an area under the curve (AUC) of 0.839, whereas the MoCA score of 23 had 54% sensitivity and 86% specificity with an AUC of 0.740. For the differentiation of AD from MCI-AD, MTx-Cp of 43.0 had 70% sensitivity and 82% specificity with an AUC of 0.799, whereas the MoCA score of 20 had 84% sensitivity and 62% specificity with an AUC of 0.767.

CONCLUSION

MemTrax can effectively detect both clinically diagnosed MCI and AD with better accuracy as compared to the MoCA based on AUCs in a Chinese cohort.

摘要

背景

临床应用中急需一种有效、可靠、易用、引人入胜且价格合理的数字化认知筛查工具。

目的

评估 MemTrax 记忆测试在中国人群中用于早期发现认知障碍的临床效用。

方法

对 50 名临床诊断为认知正常（CON）、50 名轻度认知障碍（MCI-AD）和 50 名阿尔茨海默病（AD）志愿者进行 2.5 分钟的 MemTrax 和蒙特利尔认知评估（MoCA）测试。分析比较 MemTrax 的正确反应百分比（MTx-%C）、平均反应时间（MTx-RT）和综合评分（MTx-Cp）与 MoCA 评分，并生成受试者工作特征（ROC）曲线。

结果

多元线性回归分析表明，MCI-AD 组和 AD 组的 MTx-%C、MTx-Cp 和 MoCA 评分均显著低于 CON 组（均 p≤0.001）。在 MCI-AD 与 CON 的鉴别中，MTx-%C 优化截断值为 81%时，灵敏度为 72%，特异度为 84%，曲线下面积（AUC）为 0.839；MoCA 评分 23 时，灵敏度为 54%，特异度为 86%，AUC 为 0.740。在 AD 与 MCI-AD 的鉴别中，MTx-Cp 截断值为 43.0 时，灵敏度为 70%，特异度为 82%，AUC 为 0.799；MoCA 评分 20 时，灵敏度为 84%，特异度为 62%，AUC 为 0.767。