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[副肿瘤性自身免疫性皮肤病]

[Paraneoplastic autoimmune dermatoses].

作者信息

Didona D, Hertl M

机构信息

Klinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Baldingerstr., 35043, Marburg, Deutschland.

出版信息

Hautarzt. 2021 Apr;72(4):277-287. doi: 10.1007/s00105-021-04773-w. Epub 2021 Mar 1.

DOI:10.1007/s00105-021-04773-w
PMID:33646324
Abstract

Paraneoplastic skin manifestations associated with malignancies are extremely polymorphous. Clinicians should be familiar with paraneoplastic dermatoses to establish an early diagnosis of the underlying neoplasm. Lack of familiarity with cutaneous clues for internal malignancies may delay diagnosis and treatment of cancer. In this review, we describe several paraneoplastic autoimmune dermatoses, including paraneoplastic autoimmune multiorgan syndrome, paraneoplastic bullous pemphigoid, and paraneoplastic dermatomyositis.

摘要

与恶性肿瘤相关的副肿瘤性皮肤表现极为多样。临床医生应熟悉副肿瘤性皮肤病,以便对潜在肿瘤进行早期诊断。对内部恶性肿瘤的皮肤线索缺乏了解可能会延迟癌症的诊断和治疗。在本综述中,我们描述了几种副肿瘤性自身免疫性皮肤病,包括副肿瘤性自身免疫多器官综合征、副肿瘤性大疱性类天疱疮和副肿瘤性皮肌炎。

相似文献

1
[Paraneoplastic autoimmune dermatoses].[副肿瘤性自身免疫性皮肤病]
Hautarzt. 2021 Apr;72(4):277-287. doi: 10.1007/s00105-021-04773-w. Epub 2021 Mar 1.
2
Paraneoplastic Dermatoses: A Brief General Review and an Extensive Analysis of Paraneoplastic Pemphigus and Paraneoplastic Dermatomyositis.副肿瘤性皮肤病:简要概述及对副肿瘤性天疱疮和副肿瘤性皮肌炎的详细分析。
Int J Mol Sci. 2020 Mar 21;21(6):2178. doi: 10.3390/ijms21062178.
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Autoimmune blistering dermatoses as systemic diseases.自身免疫性大疱性皮肤病作为系统性疾病
Clin Dermatol. 2014 May-Jun;32(3):364-75. doi: 10.1016/j.clindermatol.2013.11.003. Epub 2013 Nov 22.
4
Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.副肿瘤性天疱疮及与肿瘤相关的自身免疫性水疱病:特征、诊断、相关肿瘤、发病机制假说、治疗
Am J Clin Dermatol. 2017 Feb;18(1):105-126. doi: 10.1007/s40257-016-0235-z.
5
Paraneoplastic autoimmune multiorgan syndrome.副肿瘤性自身免疫性多器官综合征
Ital J Dermatol Venerol. 2021 Apr;156(2):174-183. doi: 10.23736/S2784-8671.20.06675-4. Epub 2020 Oct 16.
6
Paraneoplastic pemphigus: a brief update.副肿瘤性天疱疮:简要更新
Australas J Dermatol. 2005 Feb;46(1):1-8; quiz 9-10. doi: 10.1111/j.1440-0960.2005.126_1.x.
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Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus) with unusual manifestations and without detectable autoantibodies.伴有不寻常表现且无可检测自身抗体的副肿瘤性自身免疫性多器官综合征(副肿瘤性天疱疮)
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Paraneoplastic autoimmune Laminin-332 syndrome (PALS): Anti-Laminin-332 mucous membrane pemphigoid as a prototype.副肿瘤性自身免疫性层粘连蛋白-332 综合征(PALS):以抗层粘连蛋白-332 黏膜天疱疮为原型。
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[Bronchiolitis obliterans associated with paraneoplastic pemphigus: a paraneoplastic autoimmune multiorgan syndrome].[闭塞性细支气管炎合并副肿瘤性天疱疮:一种副肿瘤性自身免疫性多器官综合征]
Arch Bronconeumol. 2004 May;40(5):240-3. doi: 10.1016/s1579-2129(06)70091-x.
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Paraneoplastic autoimmune multiorgan syndrome in a patient with Li Fraumeni syndrome.
JAMA Dermatol. 2013 Sep;149(9):1116-7. doi: 10.1001/jamadermatol.2013.4982.

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Paraneoplastic Dermatoses: A Clue for Underlying Malignancies.副肿瘤性皮肤病:潜在恶性肿瘤的线索
J Clin Med. 2025 Feb 5;14(3):1014. doi: 10.3390/jcm14031014.
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[Paraneoplastic pemphigus with underlying Castleman's disease in a 16-year-old girl].[一名16岁女孩患副肿瘤性天疱疮伴潜在卡斯特曼病]
Dermatologie (Heidelb). 2024 Aug;75(8):641-646. doi: 10.1007/s00105-024-05328-5. Epub 2024 Apr 24.
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[Pemphigus: current and future treatment strategies].[天疱疮:当前及未来的治疗策略]

本文引用的文献

1
Amyopathic and anti-TIF1 gamma-positive dermatomyositis: analysis of a monocentric cohort and proposal to update diagnostic criteria.无肌病性及抗转录中介因子1γ阳性皮肌炎:单中心队列分析及更新诊断标准的建议
Eur J Dermatol. 2020 Jun 1;30(3):279-288. doi: 10.1684/ejd.2020.3766.
2
The polymorphous spectrum of dermatomyositis: classic features, newly described skin lesions, and rare variants.皮肌炎的多态性谱:经典特征、新描述的皮肤损伤和罕见变异。
Eur J Dermatol. 2020 Jun 1;30(3):229-242. doi: 10.1684/ejd.2020.3761.
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Successful treatment with i.v. immunoglobulin and rituximab for bronchiolitis obliterans associated with paraneoplastic pemphigus.
Dermatologie (Heidelb). 2022 Dec;74(12):915-926. doi: 10.1007/s00105-023-05246-y. Epub 2023 Oct 30.
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[Management of bullous pemphigoid and mucous membrane pemphigoid].[大疱性类天疱疮和黏膜类天疱疮的管理]
Dermatologie (Heidelb). 2022 Dec;74(12):927-936. doi: 10.1007/s00105-023-05241-3. Epub 2023 Oct 16.
静脉注射免疫球蛋白和利妥昔单抗成功治疗副肿瘤性天疱疮相关的闭塞性细支气管炎。
J Dermatol. 2020 Oct;47(10):e368-e370. doi: 10.1111/1346-8138.15496. Epub 2020 Jul 12.
4
Detection of autoantibodies against alpha-2-macroglobulin-like 1 in paraneoplastic pemphigus sera utilizing novel green fluorescent protein-based immunoassays.利用基于新型绿色荧光蛋白的免疫测定法检测副肿瘤性天疱疮血清中针对α-2-巨球蛋白样1的自身抗体。
J Dermatol Sci. 2020 Jun;98(3):173-178. doi: 10.1016/j.jdermsci.2020.04.005. Epub 2020 May 7.
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[Not Available].[无可用内容]。
J Dtsch Dermatol Ges. 2020 May;18(5):516-527. doi: 10.1111/ddg.14097_g.
6
Recent Advances in Understanding Pemphigus and Bullous Pemphigoid.对天疱疮和大疱性类天疱疮的认识的最新进展。
J Invest Dermatol. 2020 Apr;140(4):733-741. doi: 10.1016/j.jid.2019.11.005.
7
Juvenile Dermatomyositis-Clinical Phenotypes.幼年特发性皮肌炎-临床表型。
Curr Rheumatol Rep. 2019 Dec 11;21(12):74. doi: 10.1007/s11926-019-0871-4.
8
Clinical characteristics and prognosis of polymyositis and dermatomyositis associated with malignancy: a 25-year retrospective study.特发性炎性肌病合并恶性肿瘤的临床特征和预后:一项 25 年回顾性研究。
Rheumatol Int. 2019 Oct;39(10):1733-1739. doi: 10.1007/s00296-019-04428-z. Epub 2019 Aug 23.
9
Ocular mucous membrane pemphigoid: a review.眼黏膜类天疱疮:综述。
Immunol Res. 2019 Jun;67(2-3):280-289. doi: 10.1007/s12026-019-09087-7.
10
Pemphigus: Current and Future Therapeutic Strategies.天疱疮:当前和未来的治疗策略。
Front Immunol. 2019 Jun 25;10:1418. doi: 10.3389/fimmu.2019.01418. eCollection 2019.