Andersen Joel M, Starbuck Hunter F
Cinthesis, 301 Clifton Court, Cincinnati, Ohio 45221-0172, United States.
J Org Chem. 2021 Oct 15;86(20):13983-13989. doi: 10.1021/acs.joc.0c02996. Epub 2021 Mar 1.
A variety of nucleophilic aromatic substitution reactions were carried out mechanochemically to great advantage. On average, reactions rates were nine-times faster. The corresponding kinetic studies presented provide the clearest head-to-head kinetic comparisons between mechanochemical and conventional systems at identical temperatures. Attempts are provided at classifying the kinetics of one example. Removal of polar, protic solvents from these reactions presents environmental benefits to a reaction class whose kinetics are heavily dependent on such solvents.
通过机械化学方法进行了多种亲核芳香取代反应，效果显著。平均而言，反应速率快了九倍。所提供的相应动力学研究在相同温度下对机械化学体系和传统体系进行了最清晰的直接动力学比较。文中还尝试对一个例子的动力学进行分类。从这些反应中去除极性质子溶剂对一类动力学严重依赖此类溶剂的反应具有环境效益。
