Bolt Robert R A, Raby-Buck Sarah E, Ingram Katharine, Leitch Jamie A, Browne Duncan L
Department of Pharmaceutical and Biological Chemistry, University College London (UCL), School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, UK.
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK.
Angew Chem Int Ed Engl. 2022 Sep 9;61(44):e202210508. doi: 10.1002/anie.202210508.
The nickel catalyzed Suzuki-Miyaura-type coupling of aryl sulfamates and boronic acid derivatives enabled by temperature-controlled mechanochemistry via the development of a programmable PID-controlled jar heater is reported. This base-metal-catalyzed, solvent-free, all-under-air protocol was also scaled 200-fold using twin-screw extrusion technology affording decagram quantities of material.
据报道，通过开发可编程PID控制的罐式加热器，利用温控机械化学实现了芳基氨基磺酸酯与硼酸衍生物的镍催化铃木-宫浦型偶联反应。这种贱金属催化、无溶剂、全在空气中进行的反应体系还通过双螺杆挤出技术扩大了200倍规模，可制备出十克量的产物。
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