Myopia, Melatonin and Conjunctival Ultraviolet Autofluorescence: A Comparative Cross-sectional Study in Indian Myopes.

: To explore the role of outdoor light exposure by estimating ocular sun exposure measured by Conjunctival Ultraviolet Autofluorescence (CUVAF) imaging and serum melatonin levels in myopes and non-myopes.: Age and sex matched emmetropes and myopes (60 each) aged 10-25 years participated. Those with a history of ocular surgery or any ocular or systemic co-morbidity were excluded. Socio-demographic parameters, sun exposure questionnaires, indoor and outdoor activity profile, morning serum melatonin levels, sleep pattern, degree of myopia, ocular biometry and area of CUVAF on ultraviolet photography were noted and analyzed.: Mean age of myopes (18 ± 4.5 years) and emmetropes (18.5 ± 4 years) was similar ( = .523). Serum melatonin levels were significantly higher ( = .001) among myopes (89.45 pg/ml) as compared to emmetropes (52.83 pg/ml). Lifetime sun exposure was significantly lower in myopes than emmetropes ( = .0003). Area of CUVAF was inversely related to degree of myopia ( < .0001). Day time sleepiness was greater in myopes (51.7%) than emmetropes (15%) ( < .0001). There was a positive correlation between serum melatonin levels and axial length among myopes (correlation coefficient = 0.27; = .03). Age and gender had no association with serum melatonin levels.: This study demonstrates an inverse relationship between serum melatonin levels and degree of CUVAF in myopes. A novel link between serum melatonin, axial length and outdoor sun exposure is highlighted in the current study.