Respiratory and Thoracic Surgery Unit. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan, Calle 7 por 20 y 22 Num. 433, Fraccionamiento Altabrisa, Mérida, Yucatán, 97130, Mexico.
Internal Medicine Department. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan, Calle 7 por 20 y 22 Num. 433, Fraccionamiento Altabrisa, Mérida, Yucatán, 97130, Mexico.
Respir Physiol Neurobiol. 2021 Jun;288:103644. doi: 10.1016/j.resp.2021.103644. Epub 2021 Feb 27.
The purpose of this study was to examine the physiological mechanisms of persistent dyspnoea in COVID-19 survivors. Non-critical patients (n = 186) with varying degrees of COVID-19 severity reported persistent symptoms using a standardized questionnaire and underwent pulmonary function and 6-minute walk testing between 30 and 90 days following the onset of acute COVID-19 symptoms. Patients were divided into those with (n = 70) and without (n = 116) persistent dyspnoea. Patients with persistent dyspnoea had significantly lower FVC (p = 0.03), FEV (p = 0.04), D (p = 0.01), 6-minute walk distance (% predicted, p = 0.03), and end-exercise oxygen saturation (p < 0.001), and higher Borg 0-10 ratings of dyspnoea and fatigue (both p < 0.001) compared to patients without persistent dyspnoea. We have shown that dyspnoea is a common persistent symptom across varying degrees of initial COVID-19 severity. Patients with persistent dyspnoea had greater restriction on spirometry, lower D, reduced functional capacity, and increased exertional desaturation and symptoms. This suggests that there is a true physiological mechanism that may explain persistent dyspnoea after COVID-19.
这项研究的目的是探讨 COVID-19 幸存者持续性呼吸困难的生理机制。186 名非危重症患者（n=186）根据 COVID-19 严重程度的不同，使用标准化问卷报告持续性症状，并在急性 COVID-19 症状出现后 30-90 天进行肺功能和 6 分钟步行测试。患者分为有持续性呼吸困难组（n=70）和无持续性呼吸困难组（n=116）。有持续性呼吸困难的患者 FVC（p=0.03）、FEV（p=0.04）、D（p=0.01）、6 分钟步行距离（预测值的%，p=0.03）和运动结束时的血氧饱和度（p<0.001）显著降低，而呼吸困难和疲劳的 Borg 0-10 评分（均 p<0.001）显著升高，与无持续性呼吸困难的患者相比。我们已经表明，呼吸困难是 COVID-19 不同严重程度患者常见的持续性症状。有持续性呼吸困难的患者肺功能受限更明显、D 更低、功能容量更低、运动时更易发生脱氧和症状更明显。这表明可能存在一种真正的生理机制可以解释 COVID-19 后持续性呼吸困难。
