吲哚衍生物、微生物组与移植物抗宿主病。
Indole derivatives, microbiome and graft versus host disease.
机构信息
Winship Cancer Institute, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
Hematology Transplantation, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France; Université de Paris, INSERM U976, F-75010 Paris, France.
出版信息
Curr Opin Immunol. 2021 Jun;70:40-47. doi: 10.1016/j.coi.2021.02.006. Epub 2021 Feb 26.
Abstract
Graft versus host disease is a life-threatening complication following allogeneic hematopoietic stem cell transplantation driven by donor T cells reacting against disparate host antigens. Immune homeostasis within the gut plays a major role in the graft versus host response. Gut microbiota and its metabolites impact gut integrity, inflammation and immune activation within the gut. This review will focus on the role of indoles, a product of microbiota metabolism, on gut homeostasis and our current understanding on how that modulates graft versus host disease.
摘要
移植物抗宿主病是异基因造血干细胞移植后由供者 T 细胞对抗宿主抗原引起的危及生命的并发症。肠道内的免疫稳态在移植物抗宿主反应中起着重要作用。肠道微生物群及其代谢物影响肠道完整性、炎症和肠道内的免疫激活。这篇综述将重点介绍微生物群代谢产物吲哚在肠道稳态中的作用，以及我们目前对其如何调节移植物抗宿主病的理解。
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本文引用的文献
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