Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Center for Alcohol and Addiction Studies, Brown University School of Public Health Providence, RI, USA.
Drug Alcohol Depend. 2021 Apr 1;221:108617. doi: 10.1016/j.drugalcdep.2021.108617. Epub 2021 Feb 15.
The COVID-19 pandemic significantly altered treatment delivery for opioid treatment programs (OTPs) dispensing medications for opioid use disorder (MOUD). We aimed to identify patterns of substance use among MOUD patients and examine whether COVID-19-related impacts on access to healthcare varied across subgroups.
This analysis was embedded within a type 3 hybrid trial that enrolled patients across eight OTPs at the start of the pandemic. Enrolled patients reported on past-30 day use of multiple substances during their baseline assessment. Participants re-contacted in May-July 2020 completed a survey about COVID-19-related impacts on various life domains. Using latent class analysis we identified patient subgroups, and then examined group differences on a set of negative and positive COVID-19 impacts related to healthcare access.
Of the 188 trial participants, 135 (72 %) completed the survey. Latent class analysis identified three MOUD patient subgroups: minimal use (class probability: 0.25); opioid use (class probability: 0.34); and polysubstance use (class probability: 0.41). Compared to the minimal use group, the polysubstance use group reported increased substance use and difficulty accessing sterile needles, naloxone, and preferred substance. The opioid use group reported increased substance use and difficulty accessing their preferred substance. There were no significant group differences related to accessing routine or specialized healthcare or medication; or paying attention to their health.
During COVID-19, many MOUD patients reported challenges accessing care, particularly harm reduction services for patients with polysubstance use. Additional efforts, like providing wraparound support, may be necessary to serve the needs of MOUD patients.
COVID-19 大流行极大地改变了为治疗阿片类药物使用障碍(MOUD)而提供药物的阿片类药物治疗计划(OTP)的治疗方式。我们旨在确定 MOUD 患者的物质使用模式,并研究 COVID-19 对医疗保健获取的影响是否因亚组而异。
本分析嵌入在一项 3 型混合试验中,该试验在大流行开始时在 8 个 OTP 中招募了患者。入组患者在基线评估时报告了过去 30 天内多种物质的使用情况。2020 年 5 月至 7 月期间,参与者再次联系并完成了一项关于 COVID-19 对各种生活领域影响的调查。我们使用潜在类别分析确定了患者亚组,然后检查了与医疗保健获取相关的一系列负面和正面 COVID-19 影响的组间差异。
在 188 名试验参与者中,有 135 名(72%)完成了调查。潜在类别分析确定了三个 MOUD 患者亚组:最小使用(类别概率:0.25);阿片类药物使用(类别概率:0.34);和多物质使用(类别概率:0.41)。与最小使用组相比,多物质使用组报告了更多的物质使用和获取无菌针头、纳洛酮和首选物质的困难。阿片类药物使用组报告了更多的物质使用和获取首选物质的困难。在获取常规或专门医疗保健或药物方面,或关注自身健康方面,没有明显的组间差异。
在 COVID-19 期间,许多 MOUD 患者报告说在获取医疗保健方面面临挑战,特别是对于多物质使用的患者来说,减少伤害的服务更具挑战性。可能需要额外的努力,例如提供全面的支持,以满足 MOUD 患者的需求。