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本文引用的文献

1
Evaluating chronic pain as a risk factor for COVID-19 complications among New York State Medicaid beneficiaries: a retrospective claims analysis.评估慢性疼痛是否为纽约州医疗补助受益人群 COVID-19 并发症的风险因素:一项回顾性理赔分析。
Pain Med. 2023 Dec 1;24(12):1296-1305. doi: 10.1093/pm/pnad121.
2
Quality of Opioid Use Disorder Treatment for Persons With and Without Disabling Conditions.有无致残状况人群的阿片类使用障碍治疗质量。
JAMA Netw Open. 2023 Mar 1;6(3):e232052. doi: 10.1001/jamanetworkopen.2023.2052.
3
Synthesising evidence of the effects of COVID-19 regulatory changes on methadone treatment for opioid use disorder: implications for policy.综合 COVID-19 监管变化对阿片类药物使用障碍美沙酮治疗效果的证据:对政策的影响。
Lancet Public Health. 2023 Mar;8(3):e238-e246. doi: 10.1016/S2468-2667(23)00023-3.
4
The Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.阿片类药物在慢性疼痛管理中的应用:2022年美国退伍军人事务部和美国国防部临床实践指南更新概要
Ann Intern Med. 2023 Mar;176(3):388-397. doi: 10.7326/M22-2917. Epub 2023 Feb 14.
5
Telemedicine Use and Quality of Opioid Use Disorder Treatment in the US During the COVID-19 Pandemic.新冠疫情期间美国远程医疗的使用情况及其对阿片类药物使用障碍治疗质量的影响。
JAMA Netw Open. 2023 Jan 3;6(1):e2252381. doi: 10.1001/jamanetworkopen.2022.52381.
6
The impact of COVID-19 and rapid policy exemptions expanding on access to medication for opioid use disorder (MOUD): A nationwide Veterans Health Administration cohort study.COVID-19 的影响以及快速放宽政策以扩大阿片类药物使用障碍(MOUD)药物获取:一项全国退伍军人健康管理局队列研究。
Drug Alcohol Depend. 2022 Dec 1;241:109678. doi: 10.1016/j.drugalcdep.2022.109678. Epub 2022 Nov 1.
7
Chronic pain: Evidence from the national child development study.慢性疼痛:来自全国儿童发展研究的证据。
PLoS One. 2022 Nov 2;17(11):e0275095. doi: 10.1371/journal.pone.0275095. eCollection 2022.
8
Systematic Review and Meta-Analysis of the Prevalence of Chronic Pain Among Patients With Opioid Use Disorder and Receiving Opioid Substitution Therapy.阿片类药物使用障碍患者接受阿片类药物替代治疗的慢性疼痛患病率的系统评价和荟萃分析。
J Pain. 2023 Feb;24(2):192-203. doi: 10.1016/j.jpain.2022.08.008. Epub 2022 Oct 8.
9
Receipt of Telehealth Services, Receipt and Retention of Medications for Opioid Use Disorder, and Medically Treated Overdose Among Medicare Beneficiaries Before and During the COVID-19 Pandemic.医疗保险受益人的远程医疗服务的接受情况、阿片类药物使用障碍药物的获得和保留情况,以及在 COVID-19 大流行之前和期间的药物治疗过量情况。
JAMA Psychiatry. 2022 Oct 1;79(10):981-992. doi: 10.1001/jamapsychiatry.2022.2284.
10
Has the treatment gap for opioid use disorder narrowed in the U.S.?: A yearly assessment from 2010 to 2019".美国阿片类药物使用障碍的治疗差距是否缩小了?2010 年至 2019 年的年度评估。
Int J Drug Policy. 2022 Dec;110:103786. doi: 10.1016/j.drugpo.2022.103786. Epub 2022 Aug 4.

在 COVID-19 大流行期间,患有共病性阿片类药物使用障碍和慢性疼痛的患者接受阿片类药物使用障碍药物治疗的利用情况和差异。

Utilization and disparities in medication treatment for opioid use disorder among patients with comorbid opioid use disorder and chronic pain during the COVID-19 pandemic.

机构信息

Center for Opioid Epidemiology and Policy, Department of Population Health, NYU Grossman School of Medicine, New York, NY, United States.

Center for Opioid Epidemiology and Policy, Department of Population Health, NYU Grossman School of Medicine, New York, NY, United States.

出版信息

Drug Alcohol Depend. 2023 Dec 1;253:111023. doi: 10.1016/j.drugalcdep.2023.111023. Epub 2023 Nov 11.

DOI:10.1016/j.drugalcdep.2023.111023
PMID:37984034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10841620/
Abstract

BACKGROUND

The COVID-19 pandemic's impact on utilization of medications for opioid use disorder (MOUD) among patients with opioid use disorder (OUD) and chronic pain is unclear.

METHODS

We analyzed New York State (NYS) Medicaid claims from pre-pandemic (August 2019-February 2020) and pandemic (March 2020-December 2020) periods for beneficiaries with and without chronic pain. We calculated monthly proportions of patients with OUD diagnoses in 6-month-lookback windows utilizing MOUD and proportions of treatment-naïve patients initiating MOUD. We used interrupted time series to assess changes in MOUD utilization and initiation rates by medication type and by race/ethnicity.

RESULTS

Among 20,785 patients with OUD and chronic pain, 49.3% utilized MOUD (versus 60.3% without chronic pain). The pandemic did not affect utilization in either group but briefly disrupted initiation among patients with chronic pain (β=-0.009; 95% CI [-0.015, -0.002]). Overall MOUD utilization was not affected by the pandemic for any race/ethnicity but opioid treatment program (OTP) utilization was briefly disrupted for non-Hispanic Black individuals (β=-0.007 [-0.013, -0.001]). The pandemic disrupted overall MOUD initiation in non-Hispanic Black (β=-0.007 [-0.012, -0.002]) and Hispanic individuals (β=-0.010 [-0.019, -0.001]).

CONCLUSIONS

Adults with chronic pain who were enrolled in NYS Medicaid before the COVID-19 pandemic had lower MOUD utilization than those without chronic pain. MOUD initiation was briefly disrupted, with disparities especially in racial/ethnic minority groups. Flexible MOUD policy initiatives may have maintained overall treatment utilization, but disparities in initiation and care continuity remain for patients with chronic pain, and particularly for racial/ethnic minoritized subgroups.

摘要

背景

COVID-19 大流行对患有阿片类药物使用障碍(OUD)和慢性疼痛的患者使用阿片类药物使用障碍(MOUD)药物的影响尚不清楚。

方法

我们分析了纽约州(NYS)医疗补助计划在大流行前(2019 年 8 月至 2020 年 2 月)和大流行期间(2020 年 3 月至 2020 年 12 月)患有和不患有慢性疼痛的受益人的医疗保险索赔。我们计算了在 6 个月回顾期内,患有 OUD 诊断的患者利用 MOUD 的每月比例和开始使用 MOUD 的治疗初治患者的比例。我们使用中断时间序列评估了按药物类型和种族/族裔划分的 MOUD 利用率和起始率的变化。

结果

在 20785 名患有 OUD 和慢性疼痛的患者中,有 49.3%(而没有慢性疼痛的患者为 60.3%)使用 MOUD。大流行对两组患者的利用率均无影响,但在患有慢性疼痛的患者中,短期中断了起始治疗(β=-0.009;95%CI[-0.015,-0.002])。对于任何种族/族裔,大流行都没有影响整体 MOUD 利用率,但非西班牙裔黑人个体的鸦片类药物治疗计划(OTP)利用率在短期内受到干扰(β=-0.007[-0.013,-0.001])。大流行中断了非西班牙裔黑人(β=-0.007[-0.012,-0.002])和西班牙裔个体的整体 MOUD 起始治疗(β=-0.010[-0.019,-0.001])。

结论

在 COVID-19 大流行之前,参加纽约州医疗补助计划的患有慢性疼痛的成年人使用 MOUD 的比例低于没有慢性疼痛的成年人。MOUD 的起始治疗在短期内受到干扰,尤其是在少数族裔群体中存在差异。灵活的 MOUD 政策举措可能维持了整体治疗利用率,但在患有慢性疼痛的患者中,特别是在少数族裔亚群中,仍存在起始和护理连续性方面的差异。