血液金属/类金属浓度与人类精液质量和精子功能的关系：香港的一项横断面研究。
Associations between blood metal/ metalloid concentration and human semen quality and sperm function: A cross-sectional study in Hong Kong.
机构信息
Assisted Conception Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China; Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, People's Republic of China.
Assisted Conception Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
出版信息
J Trace Elem Med Biol. 2021 May;65:126735. doi: 10.1016/j.jtemb.2021.126735. Epub 2021 Feb 23.
BACKGROUND
The association between metal/metalloid exposure on human sperm quality is still inconclusive. There is a lack of data on the effect of metal/metalloid on sperm function.
METHODS
The aim of this study was to clarify the association between blood metal/metalloid concentration and traditional and functional sperm parameters, the blood concentration of Pb, Hg, Cd, As, Ni, Mo, Zn, Cu, Se, Fe, Mg, Cr and Ca of 288 men in Hong Kong were assessed by inductively coupled plasma-mass spectrometry, and sperm parameters including sperm concentration, motility, morphology, vitality, total sperm count, total motile sperm count, sperm DNA fragmentation and sperm acrosome reaction were measured. Demographic and lifestyle questionnaires were also provided for all participants. Multivariable linear regression analysis was performed to test the association between blood metal/ metalloid concentration and semen parameters after adjusting for relevant confounding variables.
RESULTS
The results showed that moderate to high level of blood Pb concentration (>27.19 μg/L) appeared to be negatively associated with sperm morphology (P < 0.05); high level of blood Cd concentration (>1.44 μg/L) was negatively associated with sperm acrosome reaction (P < 0.05); Mo was positively associated with semen volume (P < 0.05), however, high level of blood Mo concentration (>13.52 μg/L) was negatively associated with sperm vitality (P < 0.05); high level of blood Zn concentration (>6.20 mg/L) was positively associated with sperm vitality (P < 0.05); moderate level of blood Fe concentration (526.89-566.63 mg/L) was positively associated with sperm acrosome reaction (P < 0.05); moderate level of blood Ca concentration (55.92-66.10 mg/L) was positively associated with semen volume (P < 0.05); however, lower level of blood Ca concentration (45.90-55.92 mg/L) was negatively associated with sperm morphology (P < 0.05).
CONCLUSIONS
Our results suggested that the sperm function could be affected by blood Cd and Fe concentration and traditional sperm parameters could be affected by blood concentration of Mo, Zn, Pb and Ca.
背景
金属/类金属暴露与人类精子质量之间的关系仍不确定。关于金属/类金属对精子功能的影响的数据还很缺乏。
方法
本研究旨在阐明血液中金属/类金属浓度与传统和功能性精子参数之间的关系。采用电感耦合等离子体质谱法检测 288 名香港男性的血液中 Pb、Hg、Cd、As、Ni、Mo、Zn、Cu、Se、Fe、Mg、Cr 和 Ca 的浓度，并测量精子参数，包括精子浓度、活力、形态、活力、总精子数、总活动精子数、精子 DNA 碎片化和精子顶体反应。还为所有参与者提供了人口统计学和生活方式问卷。在调整了相关混杂变量后，采用多变量线性回归分析来检验血液金属/类金属浓度与精液参数之间的关系。
结果
结果表明，中高水平的血液 Pb 浓度（>27.19μg/L）似乎与精子形态呈负相关（P<0.05）；高水平的血液 Cd 浓度（>1.44μg/L）与精子顶体反应呈负相关（P<0.05）；Mo 与精液量呈正相关（P<0.05），但高水平的血液 Mo 浓度（>13.52μg/L）与精子活力呈负相关（P<0.05）；高水平的血液 Zn 浓度（>6.20mg/L）与精子活力呈正相关（P<0.05）；中水平的血液 Fe 浓度（526.89-566.63mg/L）与精子顶体反应呈正相关（P<0.05）；中水平的血液 Ca 浓度（55.92-66.10mg/L）与精液量呈正相关（P<0.05）；但低水平的血液 Ca 浓度（45.90-55.92mg/L）与精子形态呈负相关（P<0.05）。
结论
我们的结果表明，血液 Cd 和 Fe 浓度可能会影响精子功能，而传统的精子参数可能会受到血液中 Mo、Zn、Pb 和 Ca 浓度的影响。
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