Zeng Lingshuai, Zhang Xiu, Wang Xiu, Cheng Danqi, Li Ruifang, Han Bin, Wu Minmin, Zhuang Zhijia, Ren Annan, Zhou Yikai, Jing Tao
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China.
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China.
Biosens Bioelectron. 2021 May 15;180:113106. doi: 10.1016/j.bios.2021.113106. Epub 2021 Feb 20.
Bisphenol A (BPA) and its halogenated analogs tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are common environmental contaminants and a method for their simultaneous determination is urgently needed. A paper-based analytical device (PAD) was prepared using a metal-organic framework of UiO-66-NH coated with molecularly imprinted polymers (MIPs) using TBBPA as a template. The maximum adsorption capacity was 120.94 mg g and the imprinting factor was 4.07. The selective recognition ability of this PAD enabled the effective separation of TBBPA, TCBPA and BPA based on paper chromatography. Subsequently, the PAD cut into segments were used individually to determine the presence of target chemicals using a highly sensitive fluorescent method. Under ultraviolet light irradiation, UiO-66-NH acts as a photocatalyst to produce reactive oxygen species (ROS) that degrade TBBPA, TCBPA or BPA in the imprinted cavities and the fluorescent signal of 2',7'-dichlorodihydrofluorescein diacetate (HDCFDA) added as a ROS probe enabled the indirect determination of target chemicals. This method could determine BPA and its halogenated analogs in dust samples simultaneously with detection limits ranging from 0.14 to 0.30 ng g. The intraday relative standard deviation (RSD) was ≤6.8% and interday RSD was ≤8.1%. The recoveries ranged from 91.0 to 105.6% with RSD values that were ≤7.5%. The results stemmed from this method were consistent with those obtained from LC-MS/MS. It is an environmentally-friendly approach due to the degradation of target pollutants and possesses many advantages such as high selectivity, low cost and easy-to-fabrication.
双酚A（BPA）及其卤代类似物四溴双酚A（TBBPA）和四氯双酚A（TCBPA）是常见的环境污染物，因此迫切需要一种同时测定它们的方法。使用以TBBPA为模板的分子印迹聚合物（MIP）包覆的UiO-66-NH金属有机框架制备了一种纸质分析装置（PAD）。最大吸附容量为120.94 mg/g，印迹因子为4.07。该PAD的选择性识别能力基于纸色谱法实现了TBBPA、TCBPA和BPA的有效分离。随后，将切成段的PAD单独用于通过高灵敏度荧光法测定目标化学物质的存在。在紫外光照射下，UiO-66-NH作为光催化剂产生活性氧（ROS），其在印迹腔内降解TBBPA、TCBPA或BPA，添加的作为ROS探针的2',7'-二氯二氢荧光素二乙酸酯（HDCFDA）的荧光信号能够间接测定目标化学物质。该方法可同时测定灰尘样品中的BPA及其卤代类似物，检测限为0.14至0.30 ng/g。日内相对标准偏差（RSD）≤6.8%，日间RSD≤8.1%。回收率为91.0%至105.6%，RSD值≤7.5%。该方法得到的结果与LC-MS/MS获得的结果一致。由于目标污染物的降解，这是一种环保方法，具有选择性高、成本低和易于制备等许多优点。
