Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854, USA.
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854, USA.
Curr Opin Biotechnol. 2021 Jun;69:252-262. doi: 10.1016/j.copbio.2021.01.023. Epub 2021 Feb 26.
Discovery of new natural products, especially those with high biological activities and application values, is of great research significance. However, conventional methods based on the cultivation of microbial mono-cultures can hardly satisfy the increasing need of novel natural product generation. Recently, the development of co-cultures composed of different species has emerged as an effective approach for mining novel natural products. Inspired by microbial communities in nature, these co-culture systems create favorable environmental conditions to promote interactions between co-culture members for activating the natural product biosynthesis that is hard to induce otherwise. A large variety of novel natural products have been identified using this robust approach. This review summarizes the recent achievements of using cross-species co-cultures for natural products discovery and discusses the existing challenges and future directions.
发现新的天然产物，特别是那些具有高生物活性和应用价值的天然产物，具有重要的研究意义。然而，基于微生物单一培养的传统方法很难满足新型天然产物生成的日益增长的需求。最近，由不同物种组成的共培养物的发展已成为挖掘新型天然产物的有效方法。受自然界中微生物群落的启发，这些共培养系统创造了有利的环境条件，促进了共培养成员之间的相互作用，从而激活了原本难以诱导的天然产物生物合成。利用这种强大的方法已经鉴定出了大量的新型天然产物。本文综述了利用种间共培养进行天然产物发现的最新进展，并讨论了当前面临的挑战和未来的发展方向。
