Nonthakaew Napawit, Sharkey Liam K R, Pidot Sacha J
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
NPJ Antimicrob Resist. 2025 Jan 25;3(1):5. doi: 10.1038/s44259-025-00075-6.
The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. This review highlights notable examples of these compounds and explores modern approaches to unlocking their untapped biosynthetic potential. As a relatively underexplored genus, Nocardia represents a promising source for new antibiotics to combat the growing resistance crisis.
诺卡氏菌属包含130多种栖息于土壤的放线菌，其中许多是机会致病菌。除了致病性之外，诺卡氏菌还具有显著的生物合成潜力，能产生一系列多样的抗菌次生代谢产物。本综述重点介绍了这些化合物的显著例子，并探索了挖掘其未开发生物合成潜力的现代方法。作为一个相对未被充分研究的属，诺卡氏菌是对抗日益严重的耐药危机的新抗生素的一个有前景的来源。
