Food and Nutrition Department, National Institute of Health Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal; CESAM, Centre for Environmental and Marine Studies, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Avenida Padre Cruz, 1600-560 Lisboa, Portugal.
Faculty of Nutrition and Food Sciences, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; Epidemiology Research Unit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-091 Porto, Portugal.
Food Res Int. 2021 Feb;140:109863. doi: 10.1016/j.foodres.2020.109863. Epub 2020 Nov 3.
Deoxynivalenol (DON), an enteropathogenic mycotoxin produced by Fusarium species, is usually associated with adverse health outcomes such as gastrointestinal diseases and immunotoxicity. To estimate DON exposure of the Portuguese population at national level, a modelling approach, based on data from 94 Portuguese volunteers, was developed considering the inputs of the food consumption data generated within the National Food and Physical Activity Survey and the human biomonitoring data used to assess the exposure to DON. Ten models of association between DON urinary biomarkers and food items (pasta, cookies, biscuits, sweets, bread, rusks, nuts, oilseeds, beer, meat, milk) were established. Applying the most adequate model to the consumption data (n = 5811) of the general population, the exposure estimates of the Probable Daily Intake revealed that a fraction (0.1%) of the Portuguese population might exceed the Tolerable Daily Intake defined for DON. The analysis stratified by age revealed children (3.2%) and adolescents (6.0%) are more likely to exceed the Tolerable Daily Intake for DON. Although the unavoidable uncertainties, these results are important contributions to understand the exposure to this mycotoxin in Portugal, to assess the associated risk and the potential public health consequences.
脱氧雪腐镰刀菌烯醇（DON）是一种由镰刀菌属产生的肠致病性真菌毒素，通常与胃肠道疾病和免疫毒性等不良健康后果有关。为了评估葡萄牙全国人口的 DON 暴露情况，研究人员采用基于 94 名葡萄牙志愿者数据的建模方法，考虑了全国食品和身体活动调查中生成的食物消费数据以及用于评估 DON 暴露情况的人体生物监测数据的输入。研究建立了 10 种 DON 尿液生物标志物与食物（意大利面、饼干、面包、糖果、面包、脆饼干、坚果、油籽、啤酒、肉类、牛奶）之间关联的模型。将最适合的模型应用于一般人群的消费数据（n=5811），每日可能摄入量的暴露评估表明，葡萄牙有一小部分（0.1%）人口可能超过 DON 的可耐受每日摄入量。按年龄分层的分析表明，儿童（3.2%）和青少年（6.0%）更有可能超过 DON 的可耐受每日摄入量。尽管存在不可避免的不确定性，但这些结果对于了解葡萄牙的这种真菌毒素暴露情况、评估相关风险和潜在的公共卫生后果非常重要。
