Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Int Rev Neurobiol. 2021;157:245-309. doi: 10.1016/bs.irn.2020.09.004. Epub 2020 Nov 17.
Mood disorders, including major depressive disorder (MDD), are the most prevalent psychiatric illnesses, and pose an incredible burden to society, both in terms of disability and in terms of costs associated with medical care and lost work time. MDD has extremely high rates of comorbidity with substance use disorders (SUD) as many of the same neurobiological circuits and molecular mechanisms regulate the reward pathways disrupted in both conditions. MDD may induce SUDs, SUD may contribute to MDD development, or underlying vulnerabilities and common life experience may confer risk to developing both conditions. In this chapter we explore theories of MDD and SUD comorbidity, the neurobiological underpinnings of depression, overlapping cellular and molecular pathways for both conditions, and current treatment approaches for these comorbid conditions.
心境障碍，包括重度抑郁症（MDD），是最常见的精神疾病，无论是在残疾方面，还是在与医疗保健和失去工作时间相关的成本方面，都给社会带来了巨大的负担。MDD 与物质使用障碍（SUD）的共病率极高，因为许多相同的神经生物学回路和分子机制调节着两种情况下受损的奖励途径。MDD 可能导致 SUD，SUD 可能导致 MDD 的发展，或者潜在的脆弱性和共同的生活经历可能使两者都面临风险。在本章中，我们探讨了 MDD 和 SUD 共病的理论、抑郁的神经生物学基础、两种疾病重叠的细胞和分子途径，以及这些共病的当前治疗方法。
