Kortelainen M L
Department of Forensic Medicine, University of Oulu, Finland.
J Forensic Sci. 1987 Nov;32(6):1704-12.
Hypothermia and hyperthermia related cases recorded for the period 1973 to 1984 were collected from the files of the Department of Forensic Medicine, University of Oulu, and the necropsy protocols including toxicological results were analyzed. The fact that similar alcohol concentrations were found in both types of fatalities points to the poikilothermic effect of alcohol in humans, as found in animal studies. Both types of deaths seem to be associated with the alcohol elimination phase. Antidepressants and neuroleptics were most often found in the hypothermia cases, but benzodiazepines were also quite frequently present. In spite of the diminished use of barbiturates, these still appear in hypothermia fatalities. Certain other drugs that affect thermoregulation were also noted in solitary cases. Extended toxicological analysis was seldom made in the cases of hyperthermia deaths, and no firm conclusions on the poikilothermic effect of psychotropic drugs could be reached, for example. Therapeutic drug concentrations did not alone predispose the subjects to hypothermia, but appeared in connection with alcohol consumption or chronic diseases.
1973年至1984年期间记录的体温过低和体温过高相关病例取自奥卢大学法医学系档案，并对包括毒理学结果在内的尸检报告进行了分析。在两类死亡病例中发现了相似的酒精浓度，这一事实表明，正如在动物研究中发现的那样，酒精对人体具有变温效应。两类死亡似乎都与酒精消除阶段有关。在体温过低的病例中，最常发现的是抗抑郁药和抗精神病药，但苯二氮䓬类药物也相当常见。尽管巴比妥类药物的使用有所减少，但它们仍出现在体温过低的死亡病例中。在个别病例中还发现了其他一些影响体温调节的药物。例如，在体温过高死亡的病例中很少进行扩展毒理学分析，因此无法就精神药物的变温效应得出确切结论。治疗药物浓度本身并不会使受试者易患体温过低，但会在饮酒或患有慢性疾病的情况下出现。
