Department of Dermatology, Stirling Community Hospital, Stirling, UK.
Department of Dermatology and Allergology, Klinikum Vest GmbH Academic, Teaching Hospital, Recklinghausen, Germany.
Eur J Dermatol. 2021 Feb 1;31(1):17-21. doi: 10.1684/ejd.2021.3973.
This article reviews the 2020 European Society for Photodynamic Therapy (Euro-PDT) Annual Congress. Cutting edge studies included assessment of immunohistochemical variables influencing response of basal cell carcinomas and Bowen's disease to PDT with p53, the only biomarker associated with good response in both conditions. A further study indicated that analysis of molecular markers, such as PIK3R1, could help select patients with actinic keratoses who demonstrate the best response to daylight PDT. Novel delivery protocols include artificial daylight, and laser-assisted and textile PDT. The meeting learnt of novel indications including antimicrobial PDT, as well as methods to optimise daylight PDT, including combination therapy for actinic keratoses. Adverse events were reviewed and options for painless and efficient PDT assessed, including the effect of reduced drug-light interval. A smartphone application was also evaluated which may be used to assist clinicians and patients in effective dosing and timing of daylight PDT via computational algorithms using data from earth observation satellites, to send light and ultraviolet dose information directly to patients' smart phones.
这篇文章回顾了 2020 年欧洲光动力疗法学会（Euro-PDT）年会。前沿研究包括评估影响基底细胞癌和鲍恩病对 PDT 反应的免疫组织化学变量，p53 是这两种情况下唯一与良好反应相关的生物标志物。另一项研究表明，分析分子标记物，如 PIK3R1，可能有助于选择对日光 PDT 反应最佳的光化性角化病患者。新的输送方案包括人造日光、激光辅助和纺织品 PDT。会议了解到新的适应症，包括抗菌 PDT，以及优化日光 PDT 的方法，包括光化性角化病的联合治疗。还审查了不良反应，并评估了无痛、高效 PDT 的选择，包括减少药物-光照间隔的影响。还评估了一款智能手机应用程序，该程序可通过使用地球观测卫星数据的计算算法，协助临床医生和患者对日光 PDT 进行有效剂量和时间安排，并将光照和紫外线剂量信息直接发送到患者的智能手机。
