Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.
J Eur Acad Dermatol Venereol. 2012 Jun;26(6):673-9. doi: 10.1111/j.1468-3083.2011.04386.x. Epub 2011 Dec 23.
Photodynamic therapy (PDT) is an attractive therapy for non-melanoma skin cancers including actinic keratoses (AKs) because it allows treatment of large areas; it has a high response rate and results in an excellent cosmesis. However, conventional PDT for AKs is associated with inconveniently long clinic visits and discomfort during therapy. In this article, we critically review daylight-mediated PDT, which is a simpler and more tolerable treatment procedure for PDT. We review the effective light dose, efficacy and safety, the need for prior application of sunscreen, and potential clinical scope of daylight-PDT. Three randomized controlled studies have shown that daylight-mediated PDT is an effective treatment of thin AKs. Daylight-mediated PDT is nearly pain-free and more convenient for both the clinics and patients. Daylight-mediated PDT is especially suited for patients with large field-cancerized areas, which can easily be exposed to daylight. Further investigations are necessary to determine at which time of the year and in which weather conditions daylight-mediated PDT will be possible in different geographical locations.
光动力疗法（PDT）是一种有吸引力的非黑色素瘤皮肤癌治疗方法，包括光化性角化病（AK），因为它允许治疗大面积病变；它具有很高的反应率，并且美容效果极佳。然而，传统的 AK PDT 与不方便的长门诊就诊和治疗期间的不适有关。在本文中，我们批判性地回顾了日光介导的 PDT，这是一种更简单、更耐受的 PDT 治疗方法。我们回顾了有效光剂量、疗效和安全性、先前应用防晒霜的必要性以及日光-PDT 的潜在临床范围。三项随机对照研究表明，日光介导的 PDT 是治疗薄型 AK 的有效方法。日光介导的 PDT 几乎无痛，对诊所和患者都更加方便。日光介导的 PDT 特别适合大面积癌化区域的患者，这些区域很容易暴露在日光下。有必要进一步研究以确定在不同地理位置的一年中的哪个时间以及在何种天气条件下可以进行日光介导的 PDT。
